蛙血清去蛋白提取物抗缺氧作用的初步研究  

Primary Study on Anti- Hypoxia Activity of Deproteinized Frog Serum Extract

作　　者：陈博[1] 

机构地区：[1]广东医学院东莞校区生理科学实验室,广东东莞523808

出　　处：《中国药业》2013年第17期13-14,共2页China Pharmaceuticals

基　　金：广东医学院青年基金项目;项目编号:XQ1103

摘　　要：目的研究蛙血清去蛋白提取物对小鼠的抗缺氧作用。方法通过建立小鼠常压缺氧模型、急性脑缺血性缺氧模型及亚硝酸钠中毒缺氧模型,以生理盐水为空白对照,盐酸普萘洛尔为阳性对照,观察蛙血清去蛋白提取物3个剂量组(10,30,90 mg/kg)对小鼠的抗缺氧作用。结果蛙血清去蛋白提取物能显著延长模型小鼠在常压缺氧、急性脑缺血性缺氧及亚硝酸钠中毒缺氧时的存活时间。结论蛙血清去蛋白提取物具有抗缺氧作用。Objective To investigate the anti- hypoxia activity of deproteinized frog serum extract on mice. Methods With normal saline as the blank control group, and propranolol hydrochloride as the positive control group,the anti-hypoxia effect of the 3 doses（10, 30, 90 mg/kg） of deproteinized frog serum extract on the mice was observed by extablish the normobaric hypoxia mice model, acute cere- bral ischermic hypoxia mice model and sodium nitrite poisoning hypoxia mice mode. Results The deproteinized frog serum extract could significantly prolong the survival time of mice in hypoxia under ordinary pressures, acute cerebral ischemic hypoxia and sodium nitrite poisoning caused hypoxia. Conclusion Deproteinized frog serum extract has the anti- hypoxic effect on mice.

关 键 词：蛙血清去蛋白提取物 抗缺氧 小鼠 

分 类 号：R285.5[医药卫生—中药学] R282.74[医药卫生—中医学]