阿昔洛韦联合人血免疫球蛋白治疗病毒性脑炎的疗效观察  

Efficacy of Acyclovir Combined with Human Serum Immunoglobulin in Treating Viral Encephalitis

作　　者：宋振海[1] 

机构地区：[1]山东大学附属省立医院神经内科,山东济南250021

出　　处：《中国药业》2013年第17期89-90,共2页China Pharmaceuticals

摘　　要：目的探讨阿昔洛韦联合人血免疫球蛋白治疗病毒性脑炎的临床疗效。方法按随机数字法将医院2012年9月至2013年1月收治的68例病毒性脑炎患者分为两组,每组各34例,对照组单用阿昔洛韦治疗,观察组在此基础上联合应用人血免疫球蛋白,连续用药2周,比较两组治疗效果。结果对照组患者治愈5例,显效8例,有效8例,无效13例,总有效率为61.76%;观察组患者治愈8例,显效13例,有效9例,无效4例,总有效率为88.24%。两组总有效率比较,差异具有极显著性(P<0.01)。观察组患者发热、头痛、呕吐、抽搐、精神行为异常等症状消失时间明显短于对照组(P<0.05),且住院天数也明显少于对照组(P<0.01)。结论阿昔洛韦联合人血免疫球蛋白治疗病毒性脑炎可以协同增效,减少患者发热、呕吐、头痛、抽搐时间,缩短住院天数,减轻不良反应,值得临床推广。Objective To investigate the clinical efficacy of acyclovir combined with human serum immunoglobulin in treating viral encephalitis. Methods Sixty- eitht patients with viral encephalitis admitted to our hospital from September 2012 to January 2013 were randomly divided into two groups, 34 cases in each group. The control group was given aeyelovir alone, while on this basis the observa- tion group was given the combination therapy of human blood immunoglobulin. After 2 weeks, the therapeutic effects were compared be- tween the two groups. Results In the control group, 5 cases were cured, 8 cases were markedly effective, 8 eases were effective and 13 cases were ineffective, the total effective rate was 61.76%;in the observation group, 8 cases were cured, 13 cases were markedly effec- tive, 9 cases were effective and 4 cases were ineffective, the total effective rate was 88.24%. The difference of total effective rates be- tween the two groups, had extreme significance（P〈 0.01）.The sysptoms disappearance time of fever, headache, vomiting, convulsions, mental and behavioral abnormality in the observation group was significantly shorter than that in the control group, the difference be- tween the two groups was statistically significant（ P 〈0. 05）. The hospitalization days in the observation group were also significantly less than those in the control group, the difference between the two groups was statistically significant（ P〈 0. 01）. Conclusion Acyclovir combined with human serum immunoglobulin in treating viral encephalitis has synergistic effect, ang reduces fever, vomiting, headache and convulsions time, shortensed the hospitalization stay and alleviated the adverse reactions, which is worth of clinical promotion.

关 键 词：人血免疫球蛋白 阿昔洛韦 病毒性脑炎 疗效 

分 类 号：R969.4[医药卫生—药理学] R978.7[医药卫生—药学]