坦索罗辛联合排石颗粒治疗输尿管下段结石的前瞻随机对照研究  

Prospective Randomized Controlled Study on Tamsulosin Combined with Paishi Granules Electuary in Treating Lower Ureteral Stones

作　　者：徐冬娥[1] 张定国[1] 林考兴[1] 

机构地区：[1]中国人民解放军第117医院门诊部,浙江杭州310013

出　　处：《中国药业》2013年第17期95-96,共2页China Pharmaceuticals

摘　　要：目的探讨α1受体阻滞剂坦索罗辛对输尿管下段结石排石的影响。方法选择158例患者随机分为两组，结石大小4—10mm，试验组（A组）口服坦索罗辛＋排石颗粒冲剂，对照组（B组）口服排石颗粒冲剂，疗程8周，比较两组患者的排石时间、排石率、止痛药的使用量及使用率、生活质量评分和药物副作用等。结果两组患者的排石时间、排石率、止痛药的使用量及使用率、生活质量评分、药物副作用的发生率均有显著性差异（P〈0．05或P〈0．01）。结论坦索罗辛可提高输尿管下段结石的排石率，缩短排石时间。Objective To investigate the efficacy of alpha 1- receptor blocker tamsulosin in treating lower ureteral stones. Methods One hundred and fifity-eight patients with lower ureteral stones whose stone diameter were 4- 10 mm were randomly divided into the two groups. The experimental group was given tamsulosin combined with Paishi Granules Electuary, while the control group was given Paishi Granules Electuary only. The course of treatment was 8 weeks. The lithagoue time, lithagogue rate, dosage and frequency of analgesic drugs, scores of the quality of life and the adverse drug reactions were compared between the two groups. Results The lithagogue time, lithagogue rate, dosage and frequency of analgesic drugs, the scores of the quality of life and the occurrence rate of adverse drug reac- tions had statisticall significant difference between the two groups（P〈 0. 05 or P〈 0. 01）. Conclusion Tamsulosin can increase the lithagogue rate and shorten the lithagogue time in low urinary stones.

关 键 词：Α1受体阻滞剂 坦索罗辛 输尿管结石 排石时间 排石率 

分 类 号：R969.4[医药卫生—药理学] R983.2[医药卫生—药学]