73例伴附加染色体慢性髓系白血病患者的临床观察  

Clinical study of additional cytogenetic aberrations on 73 patients with chronic myeloid leukemia

作　　者：宋军[1] 朱红倩[1] 李斓[1] 肖仕珊[1] 黄竹筠[1] 贺远[1] 

机构地区：[1]贵州省人民医院血液科,贵州贵阳550002

出　　处：《遵义医学院学报》2013年第4期355-358,共4页Journal of Zunyi Medical University

基　　金：贵州省科学技术基金资助项目(NO:黔科合J字[2008]2297);贵州省社会发展科技攻关资助项目(NO:黔科合SY[2011]3050

摘　　要：目的分析附加染色体在慢性髓系白血病(CML)疾病进展中的意义。方法通过骨髓细胞短期培养法,结合G显带技术收集CML伴附加染色体异常的患者73例,并回顾性对染色体异常的类型与CML疾病进展的相关性进行评估。结果 73例CML患者中,常见的附加染色体主要为+8、+Ph、+21、i(17q)、t(v;22)。其中+8染色体异常共16例,12例发生于急变期,且16例均未检测到c-myc基因扩增信号;t(v;22)18例,15例发生于慢性期。结论如CML患者同时伴有+8附加染色体异常,往往预示患者预后不良且对含干扰素的治疗方案反应差,需要及时采用酪氨酸激酶抑制剂或异基因造血干细胞移植进行治疗。Objective This study was undertaken to evaluate the association of additional cytogenetic aberrations with the clinical outcomes of chronic myeloid leukemia（CML）.Methods A total of 73 CML patients with additional cytogentic aberrations were collected.The additional cytogentic aberrations were confirmed by short-term culture and G-banding technique.A retrospective analysis was performed to evaluate the association between abnormalities and CML clinical outcomes.Results The most frequent additional cytogenetic aberrations detected in 73 CML was t（v;22）,followed by ＋8,＋ Ph chromosome,＋ 21,isochromosome（17）,respectively.In addition,a total of 16 cases were detected ＋ 8,and 12 case were detected on BC.All of these patients showed no c-myc signal.t（v;22） was detected in 18 cases and 15 case were CP patients.Conclusion CML patients with ＋ 8 chromosomal abnormality were frequently associated with poor clinical outcomes and insensitive response to interferon-containing protocol.Tyro sine kinase inhibitors and allogeneic hematopoietic stem cell transplantation may improve their prognosis.

关 键 词：细胞遗传学 白血病 慢性 治疗 

分 类 号：R557[医药卫生—血液循环系统疾病]