3-溴-5-硝基苯基苄基醚的克级制备方法研究  

Multi-gram scale synthesis of 3-bromo-5-nitrophenyl benzyl ether

作　　者：杨帆[1] 刘许歌[1] 王应飞[1] 沈悦海[1] 

机构地区：[1]昆明理工大学生命科学与技术学院,云南昆明650500

出　　处：《云南民族大学学报（自然科学版）》2013年第5期327-329,共3页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：国家自然科学基金(81173029);云南省自然科学基金(2010ZC016)

摘　　要：报道了3-溴-5-硝基苯基苄基醚的制备方法 .苄醇对3,5-二硝基溴苯的芳香亲核取代反应极易受后续副反应的影响,对反应中碱、溶剂、浓度、温度、反应时间和投料量等因素进行了系统的研究,发现在DMF中50℃下与苄醇和叔丁醇钾反应10 min可以高产率得到克级目标产物.反应体系的颜色变化可作为判断反应终点的指标.A practical multi - gram scale synthesis of 3 - bromo - 5 - nitrophenyl benzyl ether was developed. The aromatic nucleophilic substitution of benzyl alcohol to 1 -bromo -3,5 -dinitrobenzene was found highly sensitive to the following side reactions. After a detailed evaluation of the reaction parameters, including the base, solvent, concentration, temperature, time, and reaction scale, the research found the target product could be obtained relia- bly at the multi - gram scale by stirring it with benzyl alcohol and potassium tert - butoxide in DMF at 50℃ for sev- eral minutes. The color change of the reaction system was found an accurate indicator of the end of this reaction.

关 键 词：3-溴-5-硝基苯基苄基醚 芳香亲核取代 克级制备 

分 类 号：O621.34[理学—有机化学]