肾炎康复片联合贝那普利治疗大鼠糖尿病肾病实验研究  

Experimental Study on Shenyankangfu Tablets Combined with Benazepril in the Treatment of Diabetic Nephropathy Rats

作　　者：董科[1] 田晓[1] 徐湜潺[1] 史国辉[1] 

机构地区：[1]河北联合大学附属医院,河北唐山063000

出　　处：《中医药导报》2013年第8期32-33,36,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：唐山市科技局项目(项目编号111302093a)

摘　　要：目的:探讨肾炎康复片联合贝那普利对实验性糖尿病大鼠肾脏功能和病理改变的影响。方法:SD大鼠40只,设置对照组、模型组、贝那普利治疗组、肾炎康复片治疗组、肾炎康复片和洛丁新联合治疗组,模型组及各治疗组采用STZ腹腔注射诱导大鼠糖尿病模型,成模后对照组及模型组用生理盐水灌胃,治疗组分别以肾炎康复片和洛丁新灌胃,8周后取材,检测各组大鼠空腹血糖、肾脏重量、体质量,计算肾指数;检测血肌酐、血尿素氮、24 h尿量、微量白蛋白;石蜡包埋切片HE染色,观察其病理学改变。结果:各治疗组比模型组血糖、肾指数、肾功能及病理改变均有所改善,联合治疗组改善更为显著(24 h尿量P<0.05,其他P<0.01)。结论:肾炎康复片联合贝那普利对实验性糖尿病肾病大鼠能降低血糖,减轻肾脏损害,改善肾功能。Objective： To study the effect on the changes of renal function and pathology in experimental diabetic rats by Shenyankangfu Tablet combined with Benazepril.Method： 40 SD rats were divided into control group,model group,Shenyankangfu Tablets treatment group,Benazepril treatment group and Shenyankangfu Tablet combined with Benazepril treatment group.Diabetic rats model rats in model group and treatment groups were induced by intraperitoneal injection of STZ.The control group and model group were perfused with saline,while the treatment groups were perfused with Shenyankangfu Tablet and Benazepril.After 8 weeks of administration,the level of fasting blood glucose,kidney weight,body weight and renal function indices and pathological changes were observed.Results： Compared with in model group,kidney index,renal function and pathological changes in each treatment groups were improved,and the combined treatment group improved more significantly.Conclusion： Shenyankangfu Tablets combined with Benazepril can reduce blood glucose,alleviate the damage of kidney,improve renal function in treatment of experimental diabtic nephropathy rats.

关 键 词：肾炎康复片 贝那普利 大鼠 糖尿病肾病 实验研究 

分 类 号：R255.4[医药卫生—中医内科学]