滋肾活血汤对2型糖尿病大鼠血管病变及肾脏保护的研究  

Protection of Kidney-Enrichment And Blood-Quickening Decoction on Vasculopathy and Kidney in Type 2 Diabetic Rats.

作　　者：颜国富[1] 李淑君[1] 胡仙[1] 杜亮亮[1] 

机构地区：[1]岳阳市中医院,湖南岳阳414000

出　　处：《中医药导报》2013年第8期77-79,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：岳阳市科技局资助课题(编号:2011-39)

摘　　要：目的:探讨滋肾活血汤对糖尿病(DM)大鼠血糖,空腹胰岛素,血脂,肾功能及血管炎性指标ET、NO、INS、TNF-α的影响。方法:选取健康雌性Wister大鼠42只分为模型对照组、中药组、二甲双胍组、中药+二甲双胍组、空白对照组进行灌胃,给药8周后进行生化、血管炎性指标、肾功能检测。结果:滋肾活血汤能显著降低糖尿病大鼠血清NO、INS、TNF-α、TG、BUN、CREA、UA水平。结论:滋肾活血汤能明显改善糖尿病大鼠血管炎症,并有明显的肾脏保护作用,早期联用小剂量二甲双胍时其优势更加显著。Objective： To explore the effect of Kidney-Enrichment And Blood-Quickening Decoction on blood sugar,fast ing insulin,blood fat,renal function,and the vasculitis index of ET,NO,INS and TNF-α.Methods： 42 female Wister rats were divided into model control group,Chinese medicine group,melbine group,Chinese medicine-melbine group and blank control group.After intragastric administration of 8 weeks,the biochemical indicator,vasculitis index and renal function were tested.Results： Kidney-Enrichment And Blood-Quickening Decoction can reduce the serum NO,INS,TNF-α,TG,BUN,CREA and UA in Type 2 diabetic rats.Conclusion： Kidney-Enrichment And Blood-Quickening Decoction can relieve the vas cular inflammation,with protective function on kidney.And the function was more obvious with low dosage of melbine in ear ly stage.

关 键 词：滋肾活血汤 2型糖尿病大鼠 血管病变 肾功能 

分 类 号：R285.5[医药卫生—中药学]