氟伐他汀对高血压患者颈动脉内膜中层厚度及脉压差的影响(英文)  

Influence of fluvastatin on carotid intima-media thickness and pulse pressure in patients with hypertension

作　　者：黄纪文[1] 谭健强[1] 甄锦焕[1] 冯艳翠[1] 

机构地区：[1]开平市中心医院心血管内科,广东开平529300

出　　处：《心血管康复医学杂志》2013年第4期378-381,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：分析氟伐他汀对高血压患者颈动脉内膜中层厚度(IMT)及脉压差(PP)的影响。方法:选择原发性高血压病患者62例,随机分为:氟伐他汀组(32例,在常规降压基础上加用氟伐他汀治疗)和常规治疗组(30例,予以常规降压治疗),疗程均为1年。比较两组治疗前,治疗6月及1年时血脂、PP及颈动脉IMT差异。结果:氟伐他汀组治疗后6月开始各血脂指标及PP[(66.9±7.3)mmHg比(53.1±6.2)mmHg]、IMT[(0.97±0.42)mm比(0.76±0.29)mm]均较治疗前明显改善(P均<0.05);且显著优于常规治疗组(P<0.05)。常规治疗组上述各指标治疗前后均无显著改善(P>0.05)。结论:氟伐他汀可改善高血压患者颈动脉内膜中层厚度及脉压差,值得临床推广。Objective：To analyze influence of fluvastatin on carotid intima-media thickness（IMT）and pulse pressure（PP）in patients with essential hypertension（EH）.Methods：A total of 62 EH patients were enrolled and randomly divided into fluvastatin group（n=32,received fluvastatin therapy based on routine antihypertensive therapy）and routine treatment group（n=30,received routine antihypertensive therapy）.Course of treatment was one year for all patients.Levels of blood lipids,PP and carotid IMT were compared between two groups before,six and 12 months after treatment.Results：Compared with before treatment,there were significant decrease in levels of all blood lipids,PP[（66.9±7.3）mmHg vs.（53.1±6.2）mmHg]and IMT[（0.97±0.42）mm vs.（0.76±0.29） mm]in fluvastatin group after treatment six and 12 months,and significantly improved more than those of routine treatment group,P＆lt;0.05 all.The levels of above-mentioned indexes were no significant improvement in routine treatment group before and after treatment（P＆gt;0.05）.Conclusion：Fluvastatin can improve carotid intima-media

关 键 词：血压 颈动脉 血管内膜 氟伐他汀 

分 类 号：R544.1[医药卫生—心血管疾病]