白藜芦醇/羟丙基-β-环糊精包合物的表征及体外溶出研究  

Characterization and dissolution of resveratrol/hydroxypropyl-β-cyclodextrin inclusion complex

作　　者：齐学洁[1,2] 邱超[2,3] 姜恒丽[2,3] 崔元璐[2,3] 

机构地区：[1]天津中医药大学中药学院,天津300193 [2]天津市现代中药重点实验室,天津300193 [3]天津中医药大学中医药研究院,天津300193

出　　处：《天津中医药》2013年第8期499-502,共4页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81173469)

摘　　要：[目的]制备并鉴定白藜芦醇/羟丙基-β-环糊精包合物,考察白藜芦醇与羟丙基-β-环糊精之间的摩尔质量比,并进行体外释放研究。[方法]采用冷冻干燥法制备白藜芦醇/羟丙基-β-环糊精包合物,采用红外光谱(FT-IR)、差示扫描量热分析(DSC)和X-Ray衍射分析(XRD)方法对包合物进行了结构鉴定。用高效液相色谱(HPLC)法测定包合物的载药量及其体外释放。[结果]证实白藜芦醇/羟丙基-β-环糊精包合物已经形成,主、客分子的摩尔比为1∶1,包合常数为1621M-1,溶解度和溶出速率均有所增大。[结论]白藜芦醇/羟丙基-β-环糊精包合物能显著增大药物的溶解度、稳定性和溶出速率。[Objective] Resveratrol hydroxypropyl-β-cyclodextrin（HP-β-CD） inclusion complex is prepared and characterized,stoichiometry of host and guest is determined and the dissolubility is also investigated.[Methods] The inclusion complex was prepared by freezedrying method,and characterized by Fourier-transform infrared spectroscopy（FT-IR）,differential scanning calorimetry（DSC） and X-ray diffractometry（XRD）.Drug content and release in vitro were determined by HPLC.[Results] It was defined that Resveratrol/HP-β-CD inclusion complex formed.Resveratrol/HP-β-CD was classified as AL-type with the ratio of 1：1 between host and guest,and the complexation constant was 1621M-1by the phase solubility diagram method.Compared to the drug alone,solubility and dissolving rate of inclusion complex increased.[Conclusion] The solubility,stability and dissolving rate of drug increases in inclusion complex of Resveratrol/HP-β-CD.

关 键 词：白藜芦醇 羟丙基-Β-环糊精 包合物 溶解度 

分 类 号：R285.5[医药卫生—中药学]