激素依赖性皮炎豚鼠模型皮损处SOD、MDA水平检测  

Detection of SOD and MDA in lesions of guinea pig model with corticosteroid dependent dermatitis

作　　者：钱丽洁[1] 徐东[1] 王雄[2] 袁定芬[2] 

机构地区：[1]上海市第八人民医院皮肤科,上海200233 [2]上海交通大学附属第六人民医院皮肤科,上海200233

出　　处：《世界临床药物》2013年第8期483-484,共2页World Clinical Drug

基　　金：上海市徐汇区卫生局医学科研课题(编号:SHXH201012)

摘　　要：目的探讨激素依赖性皮炎豚鼠模型皮损处超氧化物歧化酶(SOD)和丙二醛(MDA)检测的意义。方法将60只豚鼠随机分为模型组、阳性药物对照组和空白对照组,前两组分别予0.05%卤米松乳膏、单纯基质乳膏外涂45 d,空白对照组不给药,45 d后检测3组皮损中的SOD活性和MDA含量。结果与阳性对照组和空白对照组比较,模型组豚鼠皮损处SOD水平明显降低,而MDA水平增高。结论激素依赖性皮炎豚鼠模型皮损处SOD、MDA水平检测可为激素依赖性皮炎存在氧化失衡提供实验依据。Objective To investigate the affect of SOD and MDA in lesions of guinea pig with corticosteroid dependent dermatitis. Method A total of 60 guinea pigs were randomly divided into model group, positive control group and blank group. Model group and positive control group were treated with 0.05% Halometasone cream and simple matrix cream respectively for 45 days. The SOD activity and the content of MDA in the lesions of three groups were measured. Results Compared with positive control group and blank group, the SOD of guinea pig skin lesions in model group was significantly decreased, while MDA level was increased. Conclusion The detection of SOD and MDA in lesions of corticosteroid dependent dermatitis of guinea pig can provide the indication of oxidative imbalance of disease.

关 键 词：激素依赖性皮炎 超氧化物歧化酶 丙二醛 药物不良反应 

分 类 号：R758.25[医药卫生—皮肤病学与性病学] R979.5[医药卫生—临床医学]