十二烷基苯磺酸钠对雄性染毒小鼠子代生精功能的影响  

Study on LAS to Spermatogenic Function of Male Offspring Mice

作　　者：姜俊怡[1] 任春娥[1] 韩海艳[1] 乔鹏云[1] 

机构地区：[1]潍坊医学院附属医院生殖医学中心,山东潍坊261031

出　　处：《潍坊医学院学报》2013年第4期244-245,共2页Acta Academiae Medicinae Weifang

基　　金：山东省医药卫生科技发展计划项目基金

摘　　要：目的探讨十二炕基苯磺酸钠(LAS)对雄性染毒小鼠子代生精功能的影响。方法将昆明种雌、雄小鼠各120只随机分为4组.每组各30只。A1组为雄性小鼠经灌胃方式染毒LAS 2个月后交配生育的雄性小鼠;B1组为雄性小鼠经灌胃方式染毒LAS 2个月,停止染毒1个月后交配生育的雄性小鼠。A1,B1两组分别设对照组为A2,B2组。对小鼠体重、睾丸重量、精子密度、活力及畸形率、睾丸的组织学结构和超微结构进行分析。结果A1,B1两组小鼠的体重、睾丸重量与对照组相比差异无显著性(P>0.05)。精子密度、活力及畸形率有显著性差异(P<0.05)。A1,B1两组之间比较,小鼠的体重、睾丸重量、精子密度、活力及畸形率差异无显著性(P>0.05)。结论十二烷基苯磺酸钠对雄性小鼠子代的生精功能有明显影响;对停止染毒1个月后交配生育的子代雄性小鼠的生精功能同样存在毒性作用。Objective To determine the effects of LAS on spermatogenic function of male offspring mice .Methods One hun-dred and twenty Kun-ming male mice and 120 female mice were randomly divided into four groups .Group A1 was the male offspring mice of the male mice gavaged by LAS for two months;Group B1 was the male offspring mice of the male mice gavaged by LAS for two months and stopped for one month.Group A2 and group B2 were the control groups respectively .The mice weight,weight of testicle,density,viability and morphology of the sperm,the histological structure and the ultra structure of testicle were studied .Results Compared with the control groups , there was no difference in the mice weight and the weight of testicle of group A 1 and group B1.However,there was significant difference in the density,viability and morphology of the sperm .There was no difference between group A1 and group B1 in mice weight,weight of testicle, density,viability and morphology of the sperm .Conclusion Sodium dodecyl benzene sulfonate have an significant toxicity effect on the se-men quality and the structure of testicle of male offspring mice and they can＇t recover after they leaving off being gavaged for one month .

关 键 词：十二烷基苯磺酸钠 子代 生精功能 睾丸 精子 

分 类 号：R962[医药卫生—药理学]