辅助生殖技术后新生儿早产状况研究的Meta分析  

Premature Delivery of Children Born after Assisted Reproductive Technology and Spontaneous Conceptions:A Meta-Analysis of Cohort Study

作　　者：柏宏伟[1] 任春娥[1] 韩海艳[1] 乔鹏云[1] 姜俊怡[1] 

机构地区：[1]潍坊医学院附属医院生殖医学中心,山东潍坊261031

出　　处：《潍坊医学院学报》2013年第4期246-249,共4页Acta Academiae Medicinae Weifang

摘　　要：目的评价辅助生殖技术后新生儿的早产状况。方法计算机检索中国学术期刊网络出版总库,维普中文科技期刊全文数据库,PubMed,EBSCO全文数据库和Cochrane Library等,并辅以手工检索等方式,纳入辅助生殖技术后妊娠和自然妊娠的新生几早产状况比较的队列研究文献,并周RevMan 5.0软件进行Meta分析。结果共有19个研究文献纳入,新生儿共2 453288例。Meta分析结果表明:辅助生殖技术后新生儿早产发生率高于自然妊娠儿(P<0.05),其OR为2.47,95%C1为(1.87,3.27)。结论辅助生殖技术后新生儿发生早产的风险比自然妊娠儿高。因此,经辅助生殖技术后妊娠的孕妇,应积极做好产前保健工作,尽量避免早产发生。Objective To compare premature delivery of children who were born after assisted reproductive technology and after natural pregnancy.Methods Searched PubMed,EBSCO,Cochrane Library,China Academic Journal Network Publishing Database ,VIP Data-base for Chinese Technical Periodicals ,and references of the involved studies ,which included premature delivery of infants born after assisted reproductive technology and spontaneous conceptions .Cochrane Collaborations RevMan 5.0 software was used to do data analyses .Results Ninteen studies including 2 453 288 children were involved.Studies showed that the rate of preterm births in ART group was obviously higher than that in the natural pregnancy group （P〈0.05）.Conclusion Children born after ART may have higher risk of preterm births .There-fore,the pregnant women after assisted reproductive technology should make good antenatal care work and try to avoid premature delivery .

关 键 词：辅助生殖技术 新生儿 早产 META分析 

分 类 号：R714.2[医药卫生—妇产科学]