血清白细胞介素10水平与先兆流产的关系  

Study on the relationship between the serum level of interleukin 10 and threatened abortion

作　　者：宋芳[1] 赵紫薇[1] 陈晶[1] 丽丽[2] 呼斯楞[2] 包亚荣[2] 

机构地区：[1]内蒙古科技大学包头医学院组织学与胚胎学教研室,内蒙古包头014060 [2]内蒙古科技大学包头医学院,内蒙古包头014060

出　　处：《中国医药科学》2013年第17期33-35,共3页China Medicine And Pharmacy

摘　　要：目的探讨血清白细胞介素10(IL-10)水平与先兆流产的关系,及其在判断先兆流产治疗效果中的临床应用价值。方法采用酶联免疫吸附双抗体夹心法(ELISA)检测56例先兆流产患者(先兆流产组)、30例正常早期妊娠妇女(对照组),以及44例保胎成功患者(保胎成功组)、12例保胎失败患者(保胎失败组)血清中IL-10水平。结果(1)先兆流产组血清IL-10水平明显低于对照组(P<0.01);(2)治疗前,保胎成功组和保胎失败组血清IL-10水平明显低于对照组(P<0.01),而保胎成功组与保胎失败组治疗前血清IL-10水平比较,两组间差异无统计学意义(P>0.05);(3)先兆流产患者保胎成功组治疗后血清IL-10水平明显升高,与治疗前比较,差异有统计学意义(P<0.01),与对照组比较差异无统计学意义(P>0.05)。结论先兆流产患者血清IL-10水平明显降低,可作为判断先兆流产治疗效果的参考指标。Objective To study the relationship between the serum level of interleukin-10（IL-10） and the occurrence of threatened abortion, and to identify the elinieal applieation of serum level of IL-10 in patients with threatened abortion. Methods Enzyme linked immunosorbent assay（ELISA） were used to detect the level of IL-10 in 56 patients with threatened abortion （Threatened abortion group）, 30 normal pregnant women were served as compared group, and 44 patients for toeolysis treatment were served as sueeessful treatment group, other 12 ptients were belong to failed treatment group. Results （1） The serum level of IL-10 was remarkably lower than the compared group, there was a remarkable differenee between the two groups（P 〈 0.01）. （2） Bofore treatment, the serum level of IL-10 was remarkably lower than the compared group（P 〈 0.01）, however, there was no remarkable differenee between sueeessful treatment group and failed treatment group（P 〉 0.05）. （3） The serum level of IL-10 for latter treatment in sueeessful treatment group of threatened abortion, was distinctively higher than former treatment（P 〈 0.01）, There was no remarkable differenee between the latter treatment and the compared group （P 〉 0.05）. Conclusion The serum level of IL-10 signifieantly deereased in threatened abortion, it eould be used as markers in predieting the eurative effeet of the threatened abortion.

关 键 词：白细胞介素10 先兆流产 

分 类 号：R714.21[医药卫生—妇产科学]