58例早期先天梅毒患儿的临床分析  

Clinical analysis of early congenital syphilis:58 cases report

作　　者：褚岩[1] 徐子刚[1] 张立新[1] 马琳[1] 

机构地区：[1]首都医科大学附属北京儿童医院皮肤科,100045

出　　处：《北京医学》2013年第9期771-773,共3页Beijing Medical Journal

基　　金：北京市自然科学基金(编号7122064);首都医学发展科研基金(编号2009-1044)

摘　　要：目的总结早期先天梅毒患儿的临床特点、诊断及治疗方法。方法回顾性分析2002~2010年收治58例早期先天梅毒住院患儿的临床资料,男37例,女21例;年龄:生后2 h^2岁。本组临床表现包括:皮肤损害52例(89.7%),梅毒性骨膜炎44例(75.9%),肝大43例(74.1%)和脾大26例(44.8%)等。结果 56例予静脉滴注水剂青霉素G治疗,1例予口服红霉素治疗,1例予肌注苄星青霉素治疗;皮疹多于治疗7~10 d缓解或消退。42例获得随访,疗效均较好。结论早期先天梅毒临床表现多样,但以手足脱屑等皮肤表现为主,青霉素是最有效的治疗药物。Objective To investigate the clinical characteristics, diagnosis and treatment of early congenital syphilis. Methods 58 children with confirmed of early congenital syphilis were studied retrospectively in Beijing Children＇s Hospital of Capital Medical University between 2002 and 2010. Results They were 37 male and 21 female. The common clinical manifestation were skin lesions [52（89.7%）], bone involvement [44（75.9%）], hepatomegaly [43（74.1%）], splenomegaly [26（44.8%）], etc. 56 cases were treated by intravenous penicillin, one case by oral erythromycin and one case by benzathine penicillin intramuscular injection. The remission of the skin lesion appeared in the 7-10 days after treat ment. Conclusion Early congenital syphilis has various clinical manifestations but takes desquamation on hands and feet as main manifestation. Penicillin is the most effective treatment.

关 键 词：先天梅毒 临床表现 治疗 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]