血清超敏C反应蛋白和胱抑素C联合检测在冠心病中的应用  

Study of associated detection of serum hs-CRP and CysC in diagnosis of coronary heart disease

作　　者：陈文[1] 钱瑛[1] 王俊芳[1] 韦勇[1] 王琼[1] 

机构地区：[1]无锡市人民医院医学检验科,江苏无锡214023

出　　处：《国际检验医学杂志》2013年第17期2271-2272,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨联合检测超敏C反应蛋白(hs-CRP)和血清胱抑素C(CysC)对冠心病的预测价值。方法 182例已经经过冠状动脉造影确诊为冠心病的患者,分为稳定性心绞痛(SA)组(n=65)、不稳定性心绞痛(UA)组(n=72)、急性心肌梗死(AMI)组(n=45)。用免疫比浊法测定SA、UA和AMI组hs-CRP和CysC浓度,并与正常对照组的55例健康受试者进行比较分析。结果稳定性心绞痛(SA)组、不稳定性心绞痛(UA)组和急性心肌梗死(AMI)组hs-CRP和CysC水平明显高于对照组,且联合检测阳性率达91.2%,明显高于单项检测。结论血清hs-CRP与CysC联合检测对冠心病的预防、诊断及预后判断具有重要的临床价值,联合检测更为敏感。Objective To investigate the study of associated detection of serum high-sensitivity C-reactive protein（hs-CRP）and Cystatin-C（CysC）in diagnosis of coronary heart disease.Methods Patients（n=182）who underwent coronary angiography enrolled and were divided into patients with stable angina（SA,n=65）,patients with unstable angina（UA,n=72）,and patients with acute myocardial infarction（AMI,n=45）.The serum levels of hs-CRP and CysC were detected with immunoturbidimetric assay and compared with those of 55healthy subjects in the control group.Results The serum levels of hs-CRP and CysC in the SA,UA,and AMI were significantly higher than that in the control group.The positive rate in associated detection reached as high as 91.2%,and was higher than single detection.Conclusion The associated detection of serum levels of hs-CRP and CysC plays an important role in disease prediction and treatment and prognosis of patients with CHD,and associated detection is more sensitive.

关 键 词：C反应蛋白质 半胱氨酸蛋白酶抑制剂 冠心病 

分 类 号：R446.6[医药卫生—诊断学]