2-溴-6-氯吡啶的合成研究  

Synthesis of 2-bromo-6-chloropyridine

作　　者：赵春深[1,2] 宋吾燕[1,2] 吴昌云[1,2] 吴省付[1,2] 王思东[1,2] 

机构地区：[1]贵州省发酵工程与生物制药重点实验室,贵州贵阳550025 [2]贵州大学化学与化学工程学院,贵州贵阳550025

出　　处：《广东化工》2013年第18期17-17,14,共2页Guangdong Chemical Industry

基　　金：贵阳市科学计划项目(现代药业计划);合同编号:筑科合同[2012204]号

摘　　要：介绍了标题化合物的合成方法。以2,6-二氯吡啶为起始原料,经水合肼取代及溴取代两步反应合成了目标化合物,并经MS和1H NMR对其结构进行了表征。本合成路线原料易得、反应条件温和、操作简便,适合于工业化生产。反应总收率59%。In the paper, we introduced a approach to synthetize the title compound, was realized and manufactured from 2,6-dichloropyridine via tow steps. Its structure was verified by MS and 1H NMR. This synthetic route has the advantages of convenient operation and mild reaction conditions. The total product yield was 59 %. This program is suitable for industrial production.

关 键 词：2-溴-6-氯吡啶 2-6-二氯吡啶 合成 

分 类 号：O626.3[理学—有机化学]