2-溴吡啶的合成工艺研究  

The Technique Procedure of Synthesis of 2-bromopyridine

作　　者：丁世环[1] 龚艳明 

机构地区：[1]重庆能源职业学院石油化工系 [2]山东得顺源石油科技有限公司

出　　处：《广东化工》2013年第18期58-59,共2页Guangdong Chemical Industry

摘　　要：以2-氨基吡啶为原料,在40%的HBr溶液中,采用亚硝酸钠溶液为重氮化剂,合成2-溴吡啶,通过实验考察了反应条件对产率的影响。结果表明:2-氨基吡啶用量为0.08 mol,反应温度为0℃,氢溴酸和2-氨基吡啶摩尔比为1∶4.0,亚硝酸钠和2-氨基吡啶的摩尔比为1∶2.5且亚硝酸钠溶液的滴加时间为1.5 h时,产率可达到80.0%以上。In this work, 2-bromopyridine was prepared by diazotization of 2-aminopyridine in 40 % HBr solution using NaNO2 as diazotization agent. The influent factors of the reaction were investigated to find the optimum experimental conditions. The results showed that when 2-aminopyridine was 0.08 mol, the mole ratio of HBr and 2-aminopyridine was 1：4.0, the mole ratio of NaNO2 and 2-aminopyridine was 1：2.5, the dropping time of NaNO2 solution was 1.5 h, the yield reached to 80.0 %.

关 键 词：2-溴吡啶 2-氨基吡啶 重氮化 

分 类 号：TQ[化学工程]