4D PET/CT对肺部结节呼吸伪影纠正及SUV值影响的初步探讨  

Effect of 4D PET/CT on the correction of respiration artifact and SUV in pulmonary nodules

作　　者：李超敏[1] 赵艳玲[1] 李思进[2] 刘建忠[2] 武志芳[2] 武萍[2] 张艳兰[2] 郝新忠[2] 

机构地区：[1]山西医科大学医学影像学系,太原030001 [2]山西医科大学第一临床医学院核医学科

出　　处：《山西医科大学学报》2013年第9期715-718,754,共5页Journal of Shanxi Medical University

基　　金：山西省大学生创新基金资助项目(2012128);山西省科技攻关基金资助项目(20120321028-03)

摘　　要：目的通过与3D PET/CT的采集方式进行对比,探讨4D采集对肺部结节呼吸伪影纠正的应用价值。方法选择在我科进行常规3D PET/CT显像并同意进行呼吸门控4D显像的患者14例,均伴有多个肺部结节。3D PET采集时间2 min/床位,4D PET采集时间6 min/床位,分为6个呼吸时相,平均每时相1 min。SUV值由AW系统全自动分析获得。每个结节在3D PET以及4D PET的6个时相中共测量7次。结果所有患者4D和3D胸部PET/CT图像清晰,PET信噪比分别为4.00±0.35和3.98±0.55,二者之间差异没有统计学意义(Z=-1.109,P=0.267);而4D CT噪声水平较3D CT略增高,在肺结节特性显示中某些时相优于常规CT。14例患者37个肺部结节中,3D PET/CT发现呼吸伪影33个,4D PET/CT纠正伪影31个(93.9%);4D PET显像可以提高病灶的SUV值,3D和4D PET所获得的SUV max相关性非常好(r=0.971),但4D PET得到的SUV max明显高于3D PET/CT(13.69±6.70 vs 12.76±6.74,t=3.475,P=0.001)。结论采用4D PET/CT显像图像质量清晰,呼吸伪影校正良好,能达到诊断的要求,且4D PET/CT所获得的肺部结节SUV max比3D常规采集明显升高,可以为临床诊断提供更多的临床依据。Objective To explore the value of 4D PET/CT in correcting the respiration artifact of pulmonary nodules in comparison with 3D PET/CT. Methods Fourteen patients with multiple pulmonary nodules were performed PET/CT scan from May 2010 to March 2011 in department of nuclear medicine. All patients were performed with both respiratory gating and non-gating PET/CT scans. The acquisition time was set 2 min/bed for 3D PET and 6 min/bed for 4D PET. There was 6 respiratory phases with 1 min each phase for 4D PET. SUV was measured via AW workstation automatically. Every nodule was measured 7 times including 6 phases data and non- gating data. Results All 4D and 3D images in patients with chest PET/CT were clear,and the signal-to-noise ratios of those PET im- ages were 4.00 ± 0.35 and 3.98 ± 0.55, respectively. The noise level of 4D CT was slightly higher than that of 3 D CT, and the difference between 3D and 4D PET was not statistically significant （Z = - 1. 109 ,P = 0.267）. The pulmonary nodules characteristics of 4D CT images were better than those of 3D CT in some respiratory phases. A total of 33 pulmonary nodules were observed with respiratory artifacts in 3 D PET/CT, while 31 artifacts （93.9%） were corrected by 4D PET/CT. The SUVmax of 4D PET was obviously higher than that of non-gating PET（13. 69 ± 6. 70 vs 12.76±6.74,t=3.475,P=0.001） with good relativity （r=0.971）. Conclusion 4D PET/CT can correct respiratory artifact with clear images, and the SUVmax of 4D PET/CT is obviously higher than that of 3D PET/CT. 4D PET/CT scan would provide much more evidences for the clinical diagnosis.

关 键 词：PET CT 呼吸门控 标准摄取比值 肺结节 

分 类 号：R445[医药卫生—影像医学与核医学]