瑞替加滨溶液降解动力学的研究  

Degradation kinetics of retigabine in solution

作　　者：王玉霞[1] 张林林[1] 

机构地区：[1]天津大学药物科学与技术学院,天津300072

出　　处：《应用化工》2013年第9期1648-1650,1655,共4页Applied Chemical Industry

摘　　要：研究了瑞替加滨在不同温度和pH值下的降解动力学,采用反相HPLC的方法对降解后的溶液进行测定。结果表明,瑞替加滨在不同温度和不同pH值下的降解都遵循一级降解动力学,瑞替加滨的降解速率受温度和pH的影响显著,在低温、pH值为3时相对稳定。The degradation kinetics of.retigabine under different temperature and pH values were studied.And RP-HPLC method was used for the detection of the degradation samples.Results showed that the degradation met the first-order kinetics under different temperature and pH values,the degradation rate was influenced significantly by temperature and pH.Retigabine solution was relatively stable at low temperature and at pH =3.

关 键 词：瑞替加滨 降解动力学 温度 PH 

分 类 号：R917[医药卫生—药物分析学] O657.72[医药卫生—药学]