应重视辅助生殖技术助孕者孕早期超声筛查宣教  

Importance of suggestion on prenatal sonographic screening in pregnancies conceived by assisted reproductive technology during their first-trimester

作　　者：赵君利[1] 刘满梅[2] 单翠萍[1] 王海燕[2] 姜银芝[1] 徐仙[1] 哈灵侠[1] 

机构地区：[1]宁夏医科大学总医院生殖医学中心,宁夏银川750004 [2]宁夏医科大学总医院妇科,宁夏银川750004

出　　处：《宁夏医学杂志》2013年第9期796-798,共3页Ningxia Medical Journal

基　　金：宁夏留学人员择优基金资助项目;国家自然科学基金资助项目(81060051);卫生行业专项(201002013)

摘　　要：目的探讨辅助生殖技术(ART)妊娠者孕早期产前超声筛查宣教的必要性,为重视和普及该群体孕11～13+6周胎儿颈项透明层(NT)厚度筛查提供依据。方法分析体外受精/卵胞浆内单精子注射/冻融胚胎移植技术(IVF/ICSI/FET)助孕妊娠者中由生殖医师宣教的患者接受NT筛查的情况。结果 2012年1-12月IVF/ICSI/FET助孕超过孕12周者308例,自然/手术减胎后为单胎249例,占80.84%;双胎59例,占19.16%。患者均在生殖医学中心完成孕早期黄体支持随访,其中接受NT筛查宣教77例(单胎55例,双胎20例),在要求时间内完成筛查75例,依从率97.40%(75/77);发现NT异常2例,NT异常率为2.67%(2/75),其中1例胎儿颈项淋巴囊肿孕早期终止妊娠。结论 ART助孕双胎率、NT异常率高,重视和加强ART患者孕早期胎儿超声筛查宣教有助于较早、有效发现异常儿及高危儿。Objective To investigate the necessity of strengthening the education and suggestion on prenatal sonographic screening during the first trimester in pregnancies conceived by assisted reproductive technology, to provide evidence for improving the sense on fetal nuchal translucencyt （NT） hickness screening duringl 1 - 13^＋6 and popularize it among IVF/ICSI/FET pregnancies. Methods 308 pregnancies conceived by in -vitro fertilization （IVF） or intracytoplasmic sperm injection （ICSI） and （frozen embryo transfer, FET） （IVF/ICSI/FET） during 2012 lasting over 12 weeks ,75 of them who undergoing treatment and follow -up by one doctor with 11 -13^＋6 gestational weeks had been checked by ultrasound in our hospital. Fetal nuchal translucency （NT） were measured. Results There were 249 singleton pregnancies （80.84%） and 59 twin pregnancies （ 19.16% ） in total 308 pregnancies conceiving by IVF/ICSI/FET lasting over 12 weeks. All cases had finished their follow - up in our reproductive center in their first trimester for Luteini- zing hormone supplementation;NT thickness screening during 11 - 13 ＋6 was educated and suggested to 77 pregnancies and 75 cases finished their screening（97.40% ,75/77 ;2 of them were found had increased NT （ ≥ 3mm） and 1 of them had to abortion being fetal nuchal cystic hygromas. The abnormal NT thickness rate was 2.67% （2/75）. Conclusion Both twins and increased nuchal translucency rate are higher in pregnancies conceived by ART. Detection of increased nuchal translucency by ultrasound is effective, earlier in detecting abnormal foetuses or foetuses at high abnormal risk by enforce its education and suggestion in early stage of the first trimester.

关 键 词：辅助生殖技术 早孕期筛查 颈项透明层 宣教 

分 类 号：R714.8[医药卫生—妇产科学] R445.1[医药卫生—临床医学]