气相色谱-质谱联用法同时测定烟草中的1-丙醇、二甘醇、三甘醇、丙二醇与丙三醇  

Simultaneous Determination of 1-Propyl Alcohol,Diethylene Glycol, Propylene Glycol,Glycerol and Triethylene Glycol in Tobacco by Gas Chromatography-Mass Spectrometry

作　　者：刘亚[1] 何靓[1] 王文元[1] 段焰青[1] 刘娟[1] 蒋举兴[1] 

机构地区：[1]红云红河烟草(集团)有限责任公司,云南昆明650231

出　　处：《分析测试学报》2013年第9期1101-1105,共5页Journal of Instrumental Analysis

基　　金：中国烟草总公司科技项目(110201201009(BR03));云南省科技厅资助项目(2012BA015);云南中烟工业有限责任公司科技项目(2013PL03)

摘　　要：将烟草样品粉碎至40目，以1，4-丁二醇为内标，甲醇为萃取溶剂，超声萃取60 min后，以气相色谱-质谱/选择离子监测（GC-MS/SIM）法测定1-丙醇、二甘醇、三甘醇、丙二醇和丙三醇的含量。结果表明：目标化合物在1-100 μg/mL范围内线性关系良好，方法的检出限为0.05-0.48 μg/mL，回收率为90.2%-103.7%，相对标准偏差（RSDs）为0.9%-3.0%。方法的前处理简单、灵敏度高、定性定量准确，适用于烟草中多元醇的定性定量分析。A simple analysis method was developed for simultaneous determination of 1-propyl alcohol,diethylene glycol,propylene glycol,glycerol,triethylene glycol in tobacco by gas chromatography-mass spectrometry/selected ion mode（GC-MS/SIM）with 1,4-butanediol as internal standard.40 mesh powdered tobacco sample was ultrasonic extracted by methanol for 60 min directly.Under the optimal conditions,the calibration curves were linear in the range of 1-100 μg/mL,and the limits of detection（LODs） were in the range of 0.05-0.48 μg/mL.The spiked recoveries of analytes ranged from 90.2% to 103.7% with RSDs of 0.9%-3.0%.This method was suitable for the determination of 1-propyl alcohol,diethylene glycol,propylene glycol,glycerol,triethylene glycol in real tobacco samples with high sensitivity and convenient pre-treatment.

关 键 词：气相色谱-质谱联用法 烟草 1-丙醇 二甘醇 三甘醇 丙二醇 丙三醇 

分 类 号：O657.63[理学—分析化学] O622.3[理学—化学]