70对母婴麻疹野病毒中和抗体检测结果分析  

Test results analysis on wild measles virus neutralizing antibodies in 70 pairs of mother and infant

作　　者：李淑华[1] 龚向真[1] 钱晓华[1] 李崇山[2] 蒋露芳[3] 居丽雯[3] 姜庆五[3] 

机构地区：[1]上海市虹口区疾病预防控制中心,上海200082 [2]上海市疾病预防控制中心,上海200336 [3]复旦大学公共卫生学院,上海200032

出　　处：《上海预防医学》2013年第9期490-492,500,共4页Shanghai Journal of Preventive Medicine

基　　金：上海市卫生局科研计划课题资助项目(20114067);上海市公共卫生优秀学科带头人培养计划项目(GWDTR201225)

摘　　要：[目的]了解母婴的麻疹野病毒中和抗体水平及其相关性。[方法]采用中和试验的方法直接检测孕妇及新生儿的麻疹野病毒中和抗体水平并进行相关分析。[结果]孕妇及新生儿的麻疹野病毒中和抗体阳性率分别为91.52%和88.57%,平均几何滴度(GMT)分别为61.32和58.17;配对母婴的麻疹野病毒中和抗体水平呈高度正相关(r=0.899,P<0.01)。当母体的抗体滴度≥1∶16时,其子代抗体的阳性率可达100.00%。[结论]母婴的麻疹抗体水平密切相关,提高母源麻疹抗体水平应是控制低月龄小儿麻疹发病的重要措施之一。[ Objective] To investigate the level of wild - measles neutralization antibody of both mother and infant, and its correlation between the paired mother and infant. [ Methods] The wild-mea- sles neutralization antibody in the serum of the women and their infants were detected directly by a neutral- ization test （NT） methods. [ Results ] The positivity rates of neutralization antibody in mothers and their infants were 91.52% and 88.57% respectively, geometric mean title of neutralization antiboby（ GMT） being 61.32 and 58.17 respectively. And the titer of neutralization antibody was highly correlated （ r = 0. 899, P 〈 0. 01 ）between mother and infant in pairs. When the GMT of mother was ≥ 1 ： 16, the positivity rate of neutralization antibody in their infants might reach 100.00%. [ Conclusion] It is important to increase the maternal measles antibody level in order to prevent infants from measles.

关 键 词：麻疹野病毒 中和抗体 母婴配对 

分 类 号：R511.1[医药卫生—内科学]