艾叶油治疗肺心病模型大鼠肺动脉高压的实验研究  

Chinese Mugwort Leaf Oil For the Treatment of Pulmonary Arterial Hypertension in Rats with Pulmonary Heart Disease

作　　者：韩冰[1] 应茵[1] 丁晓霁[1] 孙云峰[1] 王晖[1] 

机构地区：[1]浙江省立同德医院药剂科,杭州310012

出　　处：《浙江中西医结合杂志》2013年第9期700-702,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

基　　金：浙江省中医药科学研究基金计划(No.2011ZA006)

摘　　要：目的:观察艾叶油对肺心病模型大鼠肺动脉高压的影响。方法:40只SD大鼠随机分为正常对照组、模型组和艾叶油高、低剂量组,每组10只。采用野百合碱(60mg/kg)腹腔注射建立大鼠肺心病模型,造模后正常对照组、模型组每天给予生理盐水灌胃,艾叶油高、低剂量组给于艾叶油混悬液(1.8、0.2g/kg)灌胃,连续21天。采用右心导管法测定平均右心室压(mRVP)、平均肺动脉压(mPAP)和最大肺动脉压力(Max mPAP),处死动物测定称取肺湿重(wW)、右心室游离壁(RV)、左心室加心室间隔(LV+S)质量,计算肺指数(LI)和右心肥厚指数(RVHI)。结果:模型组大鼠mRVP、mPAP和Max mPAP显著高于正常对照组(P<0.05或P<0.01),艾叶油低、高剂量组大鼠mPAP、mRVP和Max mRVP均显著低于模型组(P<0.05或P<0.01);模型组大鼠RV、LV+S、wW、RVHI及LI均显著大于正常对照组(P均<0.01);艾叶油高剂量组大鼠wW、RVHI显著低于模型组(P<0.05)。结论:艾叶油对野百合碱诱导的大鼠肺心病肺动脉高压有一定的干预作用。Objective：To observe the effect of Chinese mugwort leaf oil on pulmonary arterial hypertension in rats with pulmonary heart disease. Methods：Forty SD rats were randomly divided into control,model,and low-dose and high-dose drug groups,10 rats in each group. The animal model was established by intraperitoneally injecting monocrotaline of 60 mg/kg in the model and drug groups. Rats in the control and model groups were given saline by gavage for 21 days. The low- and high-dose groups were administered with Chinese mugwort leaf oil suspension in the same way in the same period as the above described. The mean right ventricular pressure（mRVP）,mean pulmonary arterial pressure （mPAP）,and max mPAP were measured by using right cardiac catheterization. The rats were then sacrificed for determination of lung wet weight （wW） and the weight of right ventricule （RV） and left ventricule plus septum （LV＋S）. Lung index and right ventricular hypertrophy index were calculated. Results：The mRVP,mPAP,max mPAP in the model group were higher than those of the control group （P〈0,05 or P〈0.01 ）,and those parameters in the low- and high-dose drug groups were lower than those of the model group （P〈0.05 or P〈 0.01）. The RV,LV＋S,wW,RVHI,and LI in the model group were larger than those of the control group （P〈0.01）, and the wW and RVHI in the high-dose drug group were smaller than those of the model group （P〈0.05）. Con- clusion：Chinese mugwort leaf oil may have some effect on pulmonary arterial hypertension induced by monocro- taline in rats.

关 键 词：大鼠 肺心病 肺动脉高压 艾叶油 

分 类 号：R259[医药卫生—中西医结合]