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出 处:《东华大学学报(自然科学版)》2013年第5期639-643,共5页Journal of Donghua University(Natural Science)
基 金:浙江省"生态染整与污染控制"重点创新团队资助项目(2012R10038-09);浙江省自然科学基金资助项目(Y4100034)
摘 要:在微波加热条件下,研究了姜黄素与2-氯乙醇亲核取代反应中辐射时间、辐射温度、溶剂种类、缚酸剂种类与用量、反应浓度以及反应物用量比因素对该羟乙基醚化反应的影响.研究结果表明:当该反应在水介质中使用底物用量3倍的KOH为反应的缚酸剂以及使用底物用量2.2倍的2-氯乙醇时,在95℃下微波辐射6min可获得最佳的反应结果,此时,姜黄素双羟乙基醚的产率达76.4%.研究结果为姜黄素双羟乙基醚的快速制备提供了一条有效的途径.The microwave-assisted hydroxylethyl etherification of curcumin with 2- chloroethanol was studied in detail by the impacts of irradiation time and temperature, solvents, bases and their amounts, concentrations, ratio of substrate amounts. It was found that the optimal conditions could be established with 76. 4% yield by using 3eq potassium hydroxide as the base and 2. 2eq 2-chloroethanol under microwave irradiation at 95 ℃ for 6 min in medium of water. This method could be considered as an effective approach to the preparation of curcumin hydroxylethyl diether.
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