离子色谱法测定盐酸贝那普利片的含量  

Determination of Benazepril Hydrochloride Tablets by Ion Chromatography

作　　者：楼超艳[1] 薛宇[1] 朱岩[1] 周丹[1] 

机构地区：[1]浙江大学理学院,杭州310058

出　　处：《中国无机分析化学》2013年第3期64-66,共3页Chinese Journal of Inorganic Analytical Chemistry

基　　金：浙江省大学生科技创新项目计划(2012R401030)资助

摘　　要：建立离子色谱法测定盐酸贝那普利片含量的方法。实验中选定了最佳的色谱条件为淋洗液：甲烷磺酸（6mmol／L）乙腈（35％），流速：1．0mL／min，柱温：25℃，进样量：μL。实验表明，贝那普利在0．5～25μg／mL范围内线性关系良好，相关系数r为0．9999，检测限为0．089μg／mL，加标回收率为97．96％。方法操作简单，灵敏度高、准确、重现性好，可用于盐酸贝那普利片含量的测定。A method for the determination of benazepril hydrochloride tablets by ion chromatography（IC） was established. The optimal chromatographic conditions were found as following, the mixture solution of methanesulfonic acid （6 mmol/L） and aeetonitrile （85%） was used as mobile phase; a flow rate was 1 mL/min; column temperature was 25 ℃, the injection volume was 7 μL. The experimental results indicated that the calibration curve of benazepril hydrochloride has a good linearity in the range of 0.5 25 μg/mL with the correlation coefficients of 0. 999 9. The average recovery of benazepril hydrochloride was 97.96% and the LOD was 0. 089 μg/mL. The method is proved to be simple, highly sensitive, accurate, and have a good repeatability, thus is suitable for evaluating the quality of benazepril hydrochloride tablets.

关 键 词：离子色谱法 盐酸贝那普利 甲烷磺酸 

分 类 号：O657.75[理学—分析化学] TH833[理学—化学]