血清可溶性白细胞介素2受体和可溶性肿瘤坏死因子受体Ⅱ水平在判断肺结节病活动性中的应用  

Serum soluble inerleukin-2 receptor, soluble tumor necrosis factor receptor II levels in diagnosing pulmonary sarcoidosis activity

作　　者：王彩彩[1] 黄燕[1] 路聪哲[1] 姜毅[1] 田光[2] 段蕴铀[1] 

机构地区：[1]第二军医大学海军临床医学院海军总医院呼吸内科,北京100048 [2]第二军医大学海军临床医学院海军总医院医务部,北京100048

出　　处：《中国医药》2013年第10期1393-1395,共3页China Medicine

摘　　要：目的探讨血清可溶性白细胞介素2受体（sIL-2R）和可溶性肿瘤坏死因子受体Ⅱ（sTNFRⅡ）水平在判断肺结节病活动性中的应用价值。方法52例经病理确诊的肺结节病患者中，活动期28例，非活动期24例。用酶联免疫吸附试验（ELISA）法检测其外周血血清中sIL-2R、sTNFRⅡ，用紫外分光光度法测定血管紧张素转换酶（ACE）的水平，并与30例健康志愿者（对照组）对比。结果活动期肺结节病患者血清中sIL-2R、sTNFRⅡ水平分别为（1．3±0．6）、（0．95±0．29）μg／L，明显高于对照组、非活动期肺结节病组[分别为（0．9±0．4）、（0．71±0．21）μg／L及（0．9±0．4）、（0．77±0．32）μg／L]，差异均有统计学意义（均P〈0．05）；对照组与非活动期肺结节病组患者血清中sIL-2R、sTNFRⅡ水平差异无统计学意义（P〉0．05）。活动期肺结节病患者血清中ACE与sIL-2R水平呈正相关（r=0．869，P〈0．01），与sTNFRⅡ水平无相关性（r=0．103，P〉0．05）。结论血清中sIL-2R及sTNFRⅡ可能作为评价肺结节病活动性的指标，以指导临床治疗。Objective To detect serum soluble inerleukin-2 receptor （sIL-2R）, soluble tumor necrosis factor receptor II （ sTNFR II ） and angiotensin converting enzyme （ACE） levels in active pulmonary sarcoidosis patients and normal human; to evaluate the value of sIL-2R, sTNFR II in pulmonary sarcoidosis activity. Methods Of 52 cases with pulmonary sarcoidosis, 28 cases were in active period, 24 cases were in inactive period. Serum sIL-2R and sTNFR II were detected by enzyme linked immunosorbent assay. Serum ACE level was determined by ultraviolet spectrophotometry and compared with 30 healthy volunteers. Results The serum sIL-2R and sTNFR II of patients with active pulmonary sarcoidosis were （ 1.3± 0.6）, （0.95 ±0.29） μg/L and significantly higher than those in control group and patients with inactive sarcoidosis[ （0.9 ± 0.4）, （0.71±0.21 ） μg/L and （0.9 ±0.4）, （0.77 ± 0.32） μg/L, respectively ], and there were significant differences （ P 〈 0.05 ）. There was no significant difference between patients with sarcoidosis in the inactive period and healthy volunteers（P 〉 0.05）. There was a correlation between the level of ACE and sIL-2R in patients with active pulmonary sarcoidosis （r = 0. 869, P 〈 0.01 ）, but there was no correlation between the levels of ACE and sTNFR II （r = 0. 103, P 〉 0.05 ）. Conclusion The sIL-2R and sTNFR II levels may serve as the indexes of sarcoidosis activity in order to guide the clinical treatment.

关 键 词：结节病 肺 活动性 可溶性白细胞介素2受体 可溶性肿瘤坏死因子受体Ⅱ 免疫性 

分 类 号：R563[医药卫生—呼吸系统]