2-羟基查尔酮的合成  

Synthesis of 2-Hydroxychalcone

作　　者：李艳云[1] 尹振晏[1] 

机构地区：[1]北京石油化工学院化学工程学院,北京102617

出　　处：《北京石油化工学院学报》2013年第3期58-61,共4页Journal of Beijing Institute of Petrochemical Technology

摘　　要：以苯乙酮和邻羟基苯甲醛为原料,乙醇为溶剂,氢氧化钾为催化剂合成了2-羟基查尔酮。通过正交实验研究了原料物质的量的比、反应时间、催化剂质量分数及用量对反应的影响。碱性催化合成的优化工艺条件为:原料物质的量的比n(苯乙酮)∶n(邻羟基苯甲醛)=1.0∶1.4,反应时间为6.0h,催化剂氢氧化钾的质量分数为20%(用量为40mL)。优化工艺条件下的产品收率可达77.4%。最后产品经IR光谱分析、元素分析及熔点测定进行确证。2-Hydroxychalcone was syntheszied, using acetophenone and o-hydroxybenzaldehyde as raw materials, potassium hydroxide as catalyst, ethanol as solvent. The optimum technological onditions are determinded with orthogonal experiment based on three parallel affecting factors, which was proceeded by selection of raw material ratio, reaction time and catalyst dosage,which are as follows, material molar ratio of n（acetophenone） ： n（o-hydroxy- benzaldehyde） is 1.0 ： 1.4, the dosage of catalyst is 20%（dosage.. 40 mL） for 6.0 h. Under the optimal condition, the excellent yield was odtained 77.4% and then the product was determined through the measurement of melt point, the analysis of IR and elements. The the product was target product.

关 键 词：2-羟基查尔酮 苯乙酮 邻羟基苯甲醛 氢氧化钾催化 

分 类 号：TQ244[化学工程—有机化工]