类固醇药物鼻腔局部应用的研究进展  

An overview of intranasal corticosteroids therapy

作　　者：王向东[1] 张呼和[2] 郭剑锋[2] 诸小侬[1] 顾之燕[3] 韩德民[1] 

机构地区：[1]北京市耳鼻咽喉科研究所,北京100005 [2]内蒙古医学院附属第一医院耳鼻咽喉科,内蒙古呼和浩特010059 [3]中华医学会,北京100710

出　　处：《中国耳鼻咽喉颅底外科杂志》2000年第4期245-250,共6页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：目的　回顾近年来类固醇药物鼻腔局部应用的基础与临床研究进展。方法　分析近年有关的文献 2 6篇。结果　鼻腔局部用类固醇药物对参与变应性鼻炎和鼻息肉的多种细胞和细胞因子都有广泛的抑制作用 ,临床应用能有效地改善症状 ,治疗剂量下即使长期应用也几乎没有或无全身副作用 ,鼻腔局部副作用极轻微或无。结论　鼻腔局部用类固醇药物治疗鼻炎 (变应性和非变应性 )和鼻息肉等鼻腔疾病有广泛的应用前景。Objective To review the basic and clinical developments of intranasal corticosteroids. Methods Twenty-six articles covering about ten years were analysed. Results Intranasal corticosteroids can inhibit the inflammatory cells and cytokines of rhinitis and nasal polyps, and improve the symptoms of these diseases. Basically, there is no systemic and nasal side effect. Conclusion Intranasal corticosteroids are effective as a therapy for rhinitis (allergic and nonallergic), nasal polyps and some other nasal diseases.

关 键 词：糖皮质激素 局部用药 类固醇药物 

分 类 号：R987[医药卫生—药品] R977.11[医药卫生—药学]