CRP水平及基因多态性和急性心肌梗死发病风险的关系  

The relevance among serum CRP level,CRP gene C+1444T polymorphism and the risk with acute myocardial infarction

作　　者：杨海涛[1] 何国平[1] 戚传平[2] 许联红[2] 钱亿超[1] 

机构地区：[1]江苏大学附属武进医院心血管内科,江苏常州213002 [2]江苏大学附属武进医院中心实验室,江苏常州213002

出　　处：《重庆医学》2013年第27期3222-3224,共3页Chongqing medicine

基　　金：常州市科技计划项目[常科发(2009)90号]

摘　　要：目的探讨中国苏南地区汉族人群血清C-反应蛋白(CRP)水平、CRP基因C+1444T多态性与急性心肌梗死(AMI)的相关性。方法采用聚合酶链反应-限制性片段长度多态性技术检测了227例AMI患者(AMI组)和161例非冠心病者(对照组)的CRP基因C+1444T多态性,并应用酶联免疫吸附试验测定血清CRP水平。结果 AMI组CRP基因C+1444T型分布频率为CC 82.38%、CT 17.62%、TT 0%;对照组分别为CC 86.96%、CT 13.04%、TT 0%,两组基因型分布频率之间差异无统计学意义(P>0.05)。AMI组血清CRP水平显著高于对照组,差异有统计学意义(P<0.01)。不同基因型之间的血清CRP水平比较差异均无统计学意义(P>0.05)。结论中国苏南地区汉族人群的CRP基因C+1444T多态性不增加AMI的易感性,并且不影响其血清CRP水平。Objective To investigate the relationship between serum C-reactive protein（CRP） level ,CRP gene C＋1444T poly-morphism and the risk with Acute myocardial infarction （AMI） in Chinese Han population in Sunan region .Methods The CRP gene C＋1444T polymorphism was genotyped by Polymerase reaction restriction-fragment length polymorphism （PCR-RFLP） and the serum CRP level was measured by enzyme linked immunosorbent assay （ELISA） between 227 patients with AMI（AMI group） and 161 control subjects .Results No differences were found in genotype distribution between AMI group and controls （CC 82 .38% ,CT 17 .62% ,TT 0% vs 86 .96% ,13 .04% ,0% ）（P〉0 .05） .The serum CRP level in AMI group was significantly higher than controls（P〈 0 .01） .There was no differences in the serum level between any genotypes of the CRP gene C ＋ 1444T （P〈0 .05） .Conclusion The CRP gene C＋1444T polymorphism is not associate with increased risk of AMI ,and it have no effect with the serum level in Chinese Han population in Sunan region .

关 键 词：心肌梗死 C-反应蛋白质 多态性 单核苷酸 

分 类 号：R542.22[医药卫生—心血管疾病]