左卡尼汀口服液稳定性的研究  

Study of the stability of L-carnitine oral liquid

作　　者：刘青[1] 王姿婧[1] 戴学文[1] 杨金荣[1] 房志仲[1] 

机构地区：[1]天津医科大学药学院药剂学教研室,天津市临床药物关键技术重点实验室,天津300070

出　　处：《天津医科大学学报》2013年第5期424-426,共3页Journal of Tianjin Medical University

摘　　要：目的:研究左卡尼汀口服液的稳定性,并预测其在室温下的有效期。方法:采用HPLC法测定口服液中左卡尼汀的含量,用经典恒温法预测其有效期。结果:左卡尼汀口服液的降解过程符合一级动力学过程;经典恒温法测得左卡尼汀口服液在25℃的分解速度常数K25℃=9.190 49E-05,在25℃下存放其有效期t0.9=3.19年。结论:左卡尼汀口服液有效期暂定为3.0年。Objective： To investigate the stability of L-carnitine oral liquid and to forecast its expiration date in storage at room tempera- ture. Methods： The contents of L-carnitine were determined by HPLC. The expiration date was tested by classical constant-temperature method. Results： The pyrolytic degradation kinetics of L-camitine oral liquid was corresponded with the first - order kineties. The value of constant K determined by the classical constant -temperature method was 9.190 49E-05 at 25 ℃. The calculated time for 10% disintegra- tion was 3.19 years. Conclusion： The expiration date for L-carnitine oral liquid may tentatively set on 3.0 years.

关 键 词：左卡尼汀口服液 经典恒温法 稳定性 有效期 

分 类 号：R927.11[医药卫生—药学]