高原地区老年COPD急性加重期患者血清IL-6及hs-CRP、PA表达及意义  

THE SIGNIFICANCE OF IL- 6,hs- CRP AND PA EXPRESSION IN ELDERLY PATIENTS WITH ACUTE SEVERE COPD AT HIGH ALTITUDE AREA

作　　者：陈永新[1] 王晓红[1] 马建林[1] 谢德霞[1] 胡琼[1] 马海霞[1] 

机构地区：[1]青海红十字医院,西宁810000

出　　处：《青海医学院学报》2013年第3期173-176,共4页Journal of Qinghai Medical College

摘　　要：目的探讨白介素-6(IL-6)及超敏C反应蛋白(hs-CRP)、前白蛋白(PA)在高原地区老年慢性阻塞性肺疾病(COPD)中的表达及意义。方法采用对照研究法。对高原地区32例COPD急性加重期患者治疗前、后血清中IL-6及hs-CRP、PA进行检测,并分别与平原地区老年COPD急性加重期患者进行比较。结果高原地区COPD组治疗前、后血清IL-6及Hs-CRP水平高于平原对照组(P<0.05),PA低于平原对照组(P<0.05);AECOPD患者血清IL-6与肺功能FEV1呈负相关(r=-0.75,P<0.05)。结论高原地区血清IL-6、Hs-CRP在老年AECOPD发病中的表达水平要高于平原地区,PA的表达水平低于平原地区。提示高原地区以血清IL-6、Hs-CRP、PA水平判断老年AECOPD发病进程时,要考虑高原低氧因素在其中的作用。Objective To investigate the significance IL - 6, Hs - CRP and PA expression in elderly patients with acute severe COPD at high altitude area. Methods Using comparison study, the serum IL - 6, Hs - CRP and PA levels in 32 patients with acute severe COPD before and after treatment at high altitude area were measured and compared them with the serum levels of patients at plain area. Results The serum IL -6, Hs - CRP levels in pa- tients with COPD before and after treatment at high altitude area were higher than those at plain area（P 〈 0.05 ）, the levels of PA were lower than those at plain area（ P 〈0.05 ）. There was a negative correlation between the IL - 6 levels and the pulmonary function FEV1 in patients with COPD before treatment （r = - 0.75 ,P 〈0.05）. Con- clusion The serum IL - 6 and Hs - CRP levels in patients with COPD before and after treatment at high altitude are- a are higher than those at plain area, the levels of PA are lower than those at plain area. The effect of hypoxia should be considered when evaluating the serum IL- 6, Hs -CRP and PA levels involving the COPD process at high alti- tude area.

关 键 词：高原地区 慢性阻塞性肺疾病 白介素-6超敏C反应蛋白 前白蛋白 肺功能 

分 类 号：R563.3[医药卫生—呼吸系统]