血清GPDA在上消化道出血中的变化分析  

Change analysis on serum GPDA in upper gastrointestinal bleeding

作　　者：张桂[1] 汤泽生[1] 赖宝艺 石庆新 

机构地区：[1]台州市中医院检验科,浙江台州318000 [2]台州医院路桥院区检验科,浙江台州318000

出　　处：《检验医学》2013年第9期793-795,共3页Laboratory Medicine

摘　　要：目的探讨血清甘氨酰脯氨酸二肽氨基肽酶(GPDA)与上消化道出血(UGIB)的关系。方法测定33例UGIB患者(UGIB组)和33例健康体检者(正常对照组)血清GPDA和血尿素(Urea)浓度,UGIB组按性别和年龄(<60岁、≥60岁)分别分组并进行统计学分析。结果 UGIB组和正常对照组血清GPDA及Urea浓度差异有统计学意义(P=0.000)。UGIB组血清GPDA和Urea浓度不同年龄之间差异有统计学意义(P<0.01),但不同性别之间差异无统计学意义(P>0.05)。UGIB组GPDA和Urea呈明显负相关[相关系数(r)=-0.585,P<0.01]。受试者工作特征(ROC)曲线显示GPDA和Urea的曲线下面积(AUC)分别为0.893和0.769。当GPDA和Urea的Cut-off值分别为69.20 U/L、8.25 mmol/L时,其灵敏度分别为97.0%、63.6%,特异性分别为69.7%、97.0%。结论血清GPDA在UGIB时明显降低,可能在其病程中有重要作用。Objective To investigate the relationship of serum glycyl-proline dipeptidyl aminopeptidase （GPDA） and upper gastrointestinal bleeding （UGIB）. Methods Serum GPDA and urea concentrations were measured in 33 patients with UGIB （UGIB group）and 33 healthy subjects （control group）. The UGIB group was classified according sex and age （ 〈60 years old and ≥60 years old）. The results were analyzed statisically. Results Serum GPDA and urea concentrations between UGIB group and control group were significant statistically （P = 0. 000）. The concentrations of serum GPDA and urea in different age groups had statistical significance （ P 〈 O. 01 ）. There was no statistical significance between male and female groups （ P 〉 0. 05 ）. There was a negative correlation of GPDA and urea concentrations in UGIB group [ coefficient of correlation （r） = -0. 585, P 〈 0.01 ]. Receiver operating characteristic （ROC） curve showed that the areas under the ROC curve （AUC） were O. 893 and 0. 769 for GPDA and urea. When the cut-off values of GPDA and urea were 69.20 U/L and 8.25 mmol/L, the sensitivities were 97.0% and 63.6%, and the specificities were 69.7% and 97.0%. Conclusions Serum GPDA reduces significantly when UGIB, and GPDA may play an important role in the course of UGIB.

关 键 词：甘氨酰脯氨酸二肽氨基肽酶 尿素 上消化道出血 

分 类 号：Q556[生物学—生物化学]