青龙衣抗肿瘤成分的研究  

Anti-tumor Constituents from the Pericarps of Juglans Regia Max

作　　者：周媛媛[1] 付蕾[1] 金阳[1] 葛正华[1] 齐凤琴[1] 郭冷秋[1] 刘全宇 杨炳友[1] 匡海学[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江省兽药饲料监察所,黑龙江哈尔滨150040

出　　处：《中医药学报》2013年第4期70-71,共2页Acta Chinese Medicine and Pharmacology

基　　金：黑龙江省教育厅科学技术研究项目资助(No.12521499)

摘　　要：探寻青龙衣活性部位中具有细胞毒活性的化学成分。结合大孔吸附树脂、硅胶柱色谱等多种分离手段对青龙衣活性部位进行了系统分离,并利用1D,2D-NMR等方法确定了化合物的结构。研究共分离得到6个化学成分,分别为白桦脂酸(Ⅰ),3-乙酰白桦脂酸(Ⅱ),正二十六烷醇(Ⅲ),丁香脂素(Ⅳ),丁香醛(Ⅴ),邻苯二甲酸二异丁酯(Ⅵ)。其中化合物Ⅰ至Ⅵ首次从青龙衣中分离得到。To search the products with cytotoxic activity from the pericarps of Juglans regia Max.The compounds were isolated by chromatography with AB-8 resin and silica gel columns etc.,which were identified by 1D,2D-NMR analysis.They were betulinic acid（Ⅰ）,3-O-acetyl betulinic acid（Ⅱ）,hexacosanol（Ⅲ）,syringaresinol（Ⅳ）,syringaldehyde（Ⅴ）,diisobutyl phthalate（Ⅵ）.All of them were isolated from Qinglongyi for the first time.

关 键 词：青龙衣 抗肿瘤 化学成分 

分 类 号：R284[医药卫生—中药学]