栀子大黄汤颗粒剂质量标准研究  

Quality Standard of Zhizi Dahuangtang Granules

作　　者：王一[1] 田明[1] 冷志爽[1] 孙慧琳[1] 刘珍[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药学报》2013年第4期75-78,共4页Acta Chinese Medicine and Pharmacology

摘　　要：目的:建立栀子大黄汤颗粒剂的质量标准。方法:对栀子大黄汤颗粒剂中的栀子、大黄和枳实进行了薄层色谱鉴别;采用高效液相色谱法测定栀子苷含量。结果:栀子苷在0.2375～1.1875μg范围内呈良好的线性关系,r=0.999 5,平均加样回收率为100.80%,RSD为2.46%。结论:该方法可以有效的控制栀子大黄汤颗粒剂的质量。Objective： To establish the quality standard for Zhizi Dahuangtang granules.Methods： Gardenia,Radix et rhizome rhei and Fructus aurantii immaturus in Zhizi Dahuangtang granules were identified by TLC,and the contents of Gardenia glucoside were determined by HPLC.Results： The Gardenia glucoside was linear in the range of 0.2375 ～ 1.1875μg,r = 0.999 5,and average recovery rate was 100.80%,RSD = 2.46%.Conclusion： The quality of Zhizi Dahuangtang granules can be controlled effectively according to the method.

关 键 词：栀子大黄汤颗粒剂 质量标准 薄层色谱 高效液相色谱 

分 类 号：R284.1[医药卫生—中药学]