电喷雾-质谱研究A环不同取代基对黄酮类化合物裂解途径的影响  

Study on different substituents in A-ring effect on fragmentation pathway of flavonoids using electrospray ion trap mass spectrometry

作　　者：林宏英[1] 黄建梅[1] 段天璇[1] 谭鹏[1] 刘永刚[1] 李江宁[2] 

机构地区：[1]北京中医药大学,北京100102 [2]北京市药品监督管理局,北京100053

出　　处：《中国测试》2013年第5期59-61,64,共4页China Measurement & Test

基　　金：国家自然科学基金项目(30901959)

摘　　要：选择槲皮素、葛根素、黄芩苷、朝藿定C和野黄芩苷为研究对象,在负离子检测方式下,采用电喷雾-质谱法(ESI-MS)研究A环不同取代基对自身裂解途径的影响。结果发现,该类化合物主要发生了脱糖、脱CO、脱水和RDA反应,进一步分析发现,A环上不同的取代基对自身质谱裂解途经影响较大,其裂解途径有显著差异,且H2O分子的丢失可以成为判断A环取代基信息的一种方法。A环取代基不同黄酮类化合物的质谱裂解规律有助于复杂黄酮类化合物的快速检测和结构解析。Under negative ion mode, electrospray ionization mass spectrometry （ESI-MS） was used to study on different substituents in A-ring effect on fragmentation pathway of flavonoids. the fragmentation, RDA cleavage was detected and fragmentation. Different substituents in A-ring the loss of H2O molecular could be a marker During CO and H2O were usually lost during the affected fragmentation obviously, and among them, to judge the substituent in A-ring. The results will be helpful in identifying the structures of flavonoids rapidly with the method of mass spectrometry

关 键 词：电喷雾-质谱 黄酮类化合物 裂解特征 RDA裂解 

分 类 号：TQ406.72[化学工程] TQ463.24