中药金莲花药效组分抗炎镇痛作用研究  

Anti-inflammatory Analgesic Pharmacological Effects of Flos Trollii Chinensis and Its Active Components Alignment

作　　者：杨静伟[1] 张贵君[2] 吴明侠[3] 杨晶凡[3] 

机构地区：[1]黑龙江省药品审评认证中心,黑龙江哈尔滨150090 [2]北京中医药大学,北京100102 [3]河南中医学院,河南郑州450008

出　　处：《中国药物评价》2013年第4期210-213,共4页Chinese Journal of Drug Evaluation

基　　金：广东省教育部产学研项目(项目编号:2007B090400085);河南中医学院博士科研基金项目(项目编号:BSJJ2009-10)

摘　　要：目的:研究金莲花药效组分及金莲花水煎液的抗炎镇痛作用。方法:通过抗炎、镇痛药理实验观察金莲花水煎液及其药效组分的药理活性。结果:通过金莲花水煎剂组与其药效组分高、中、低剂量组比较,金莲花水煎剂及其药效组分中、高剂量组与模型组比较均有显著性差异(P<0.05),说明均具有抗炎和镇痛作用。金莲花水煎剂组与金莲花药效组分中剂量组间无显著性差异(P>0.05)。金莲花水煎剂及其药效组分均不能缓解热板致小鼠疼痛,与模型组比较无显著性差异(P>0.05),说明其不具有中枢镇痛作用。结论:金莲花水煎液具有抗炎镇痛药理作用,用于治疗咽炎和上呼吸道感染是有药理依据的。金莲花药效组分与金莲花水煎液药理作用无显著性差异,金莲花药效组分一定程度上可以反映金莲花的抗炎镇痛药理作用。Objective： To investigate the in vivo anti-inflammatory of the water extract from Flos Trollii Chinensis and its active components alignment. Methods： A group of anti-inflammatory and analgesic pharmacological experiments were employed to observe the antagonistic effect. Results： Both Flos Trollii Chinensis group and active compounds alignment group have effect on anti-inflammatory pharmaco-experiment and relieving pain experiment（P 〈 0.05 ）. There are no marked difference between Flos Trollii Chinensis group and active compounds alignment group（P 〉 0. 05）. Conclusion： The water extract frome Flos Trollii Chinensis have anti-inflammatory and analgesic effect which is related to clinical application. The active compounds alignment of Flos Trollii Chinensis can reflect the efficacy of Flos Trollii Chinensis to a certain degree.

关 键 词：金莲花 药效组分 抗炎 镇痛 

分 类 号：R285.5[医药卫生—中药学]