2型糖尿病患者血糖控制与良性前列腺增生的相关性研究  

Correlation of Diabetes Control with Benign Prostatic Hyperplasia in T2DM Patients

作　　者：褚琳[1] 陈陵霞[1] 苗懿德[1] 刘杰[1] 宝辉[1] 魏雅楠[1] 郏蓉[1] 苏琳[1] 张庆文[1] 李卫[1] 

机构地区：[1]北京大学人民医院老年科,北京市100044

出　　处：《中国全科医学》2013年第23期2671-2673,共3页Chinese General Practice

摘　　要：目的探讨2型糖尿病(T2DM)患者血糖控制与良性前列腺增生(BPH)的相关性。方法选择2010年10月—2012年8月我院老年科住院男性患者154例,分为对照组67例、血糖控制达标组46例和血糖控制不达标组41例。测量各组血压、身高、体质量,计算体质指数(BMI);检测各组空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1c)、前列腺特异性抗原(PSA)等。超声测量前列腺纵径、横径及前后径,计算前列腺体积(PV)及PV年增长率。结果血糖控制不达标组PV明显高于对照组和血糖控制达标组(q值分别为-3.02和-2.00,P<0.05);血糖控制不达标组PV年增长率明显高于对照组和血糖控制达标组(q值分别为-3.19和-2.48,P<0.05);Pearson相关分析结果显示,HbA1c、FPG、PSA与PV呈正相关(r值分别为0.260、0.195、0.363,P<0.05),HDL-C与PV呈负相关(r=-0.192,P<0.05);HbA1c、FPG、LDL-C、PSA与PV年增长率呈正相关(r值分别为0.272、0.219、0.164、0.348,P<0.05),HDL-C与PV年增长率呈负相关(r=-0.216,P<0.05)。结论良好的血糖控制可有效减慢前列腺体积的增长速度,延缓BPH病情进展。Objective To evaluate the relationship between diabetes control and benign prostatic hyperplasia （BPH） in type 2 diabetes mellitus （T2DM）. Methods Totally 154 male T2DM patients were divided into groups A （control group, n = 67）, B （ blood glucose controlled to standard, n = 46）, C （blood glucose controlled not to standard, n = 41 ）. Blood pres- sure, body weight, body height were measured, body mass index （BMI） calculated, levels of serum fast glucose （FPG）, to- tal cholesterol （TC）, triglycerides （TG）, low -density lipoprotein cholesterol （LDL- C）, high -density lipoprotein choles- terol （HDL - C）, glycosylated hemoglobin （ HbA1c ） and prostate - specific antigen （PSA） detected. Total prostate volume （PV） were measured by ultrasound. Results PV increased significantly in group C as compared with groups A and B （q = -3.02, -2. 00, P 〈 0.05 ） ; Annual PV growth rate was significantly higher in group C than in groups A, B （q = -3. 19, -2.48, P〈0.05）; By Pearson correlation analysis, PV was positively correlated with HbA1c, FPG, PSA （r = 0.260, 0. 195, 0. 363, P 〈0. 05 ）, negatively with HDL- C （r = -0. 192, P 〈 0.05 ） ; Annual PV growth rate was positively corre- lated with HbA1c, FPG, LDL - C and PSA （ r = 0. 272, 0. 219, 0. 164, 0. 348, P 〈 0. 05）, negatively with HDL - C （r = - 0. 216, P 〈 0. 05）. Conclusion Well controlling blood glucose can slow down effectively the growth rate of PV and delay BPH progression.

关 键 词：前列腺增生 糖尿病 2型 血糖 

分 类 号：R587.1[医药卫生—内分泌] R697.32[医药卫生—内科学]