维汉民族高血压伴阻塞性睡眠呼吸暂停低通气综合征患者动脉硬化差异性研究  

Atherosclerosis in Uygur and Han Patients with Hypertension Accompanied by OSAHS: A Difference Analysis

作　　者：陈玉岚[1] 孙丽[1] 珠勒皮亚.司马义 张向阳[1] 徐新娟[1] 陈曦[1] 沙巴尔.肉孜阿吉 

机构地区：[1]新疆医科大学第一附属医院高血压科,新疆维吾尔自治区乌鲁木齐市830054

出　　处：《中国全科医学》2013年第23期2702-2705,共4页Chinese General Practice

摘　　要：目的探讨新疆维吾尔族和汉族高血压伴阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者动脉硬化的差异性。方法回顾性分析确诊为高血压伴OSAHS的183例患者病历资料,按民族不同分为两组:汉族组144例,维吾尔族组39例。收集两组患者临床资料和实验室检查结果,所有受试对象进行颈动脉超声、四肢多普勒血流图、24h动态血压和多导睡眠图监测。结果 (1)维吾尔族组体质指数(BMI)〔(32±4)kg/m2比(28±4)kg/m2〕、纤维蛋白原(Fg)〔(3.45±0.59)g/L比(3.16±0.63)g/L〕及脉压(PP)〔(57±13)mm Hg比(49±11)mm Hg〕高于汉族组,三酰甘油低于汉族组〔(2.10±2.00)mmol/L比(2.76±2.36)mmol/L〕,差异均有统计学意义(P<0.01)。(2)维吾尔族组颈动脉内膜中层厚度(IMT)大于汉族组〔(0.13±0.05)cm比(0.11±0.08)cm〕,左、右踝臂指数(ABI)小于汉族组〔(1.10±0.09)比(1.14±0.08)、(1.10±0.10)比(1.15±0.08)〕,动脉硬化发生率大于汉族组(46.2%比29.9%),差异均有统计学意义(P<0.05),两组左右脉搏波传导速度(PWV)间差异无统计学意义(P>0.05)。(3)两组患者血浆肾素、血管紧张素、醛固酮活性间差异均无统计学意义(P>0.05)。结论高血压伴OSAHS患者中维吾尔族患者较汉族患者更易发生动脉硬化且动脉硬化程度更加严重,这可能与维吾尔族患者BMI、Fg及PP高于汉族有一定联系。Objective To explore the difference of atherosclerosis in Uygur and Han hypertensive patients with ob- structive sleep apnea hypopnea syndrome （OSAHS）. Methods A retrospective study was performed in 183 hypertensive pa- tients with OSAHS, who were divided, according to nationality, into groups Uygur （n = 39） and Han （n = 144）. The clinical foundation data and laboratory test results were collected. All patients underwent carotid artery uhrasonography, doppler blood flow pattem, polysomnography （PSG） and 24 - hour Hoher - ECG. Results （ 1 ） Group Uygur had higher levels of body mass index （BMI）, Fibrinogen （Fg） and pulse pressure （PP）, and a lower level of triacylglycerol than group Han [ （32 ± 4） kg/m2vs. （28±4） kg/m2, （3.45±0.59） g/Lvs. （3.16±0.63） g/L, （57±13） mmHgvs. （49±11） mmHg, （2. 10 ±2. 00） mmol/L vs. （2. 76 ±2. 36） mmol/L, respectively ], the difference was significant （P 〈0. 01）. （2） Carotid intima - media thickness was greater, left and right ankle - brachial index （ ABI ） lower in Uygur group than in Han group [ （0.13±0.05）cmvs. （0.11±0.08）cm, （1.10±0.09）vs. （1.14±0.08）, （1.10±0.10） vs. （1.15±0.08）, re- spectively3 ; The incidence of atherosclerosis higher （46. 2% vs. 29. 9% ） , the difference was significant （ P 〈 0. 05 ） ; No difference was noted in pulse wave velocity between 2 groups （ P 〉 0. 05 ）. （ 3 ） There was no significant difference in plasma rennin, angiotensin, aldosterone activity between 2 groups （P 〉 0. 05）. Conclusion Uygur hypertensive patients with OSAHA are more susceptible to atherosclerosis than Han patients and the disease is usually more severe, which may be related to Uygur having higher BMI, Fg and PP.

关 键 词：睡眠呼吸暂停 阻塞性 高血压 动脉硬化 维吾尔族 汉族 

分 类 号：R563.9[医药卫生—呼吸系统]