不同剂量维生素E预防早产儿贫血的效果研究  

Therapeutic Effects of Different Dosages of Vitamin E in the Prevention of Anemia in Premature Children

作　　者：石礼锋[1] 王平[1] 付德龙[1] 张运玲[1] 李会会[1] 

机构地区：[1]山东省滕州市中心人民医院新生儿科,277500

出　　处：《中国全科医学》2013年第23期2743-2745,共3页Chinese General Practice

摘　　要：目的探讨不同剂量维生素E预防早产儿贫血的效果。方法选择我院新生儿监护病房(NICU)2009年10月—2011年10月收治的早产儿60例为研究对象,按入院顺序分为A、B、C 3组,每组20例。A组给予常规配方奶喂养及部分静脉营养支持治疗;B组在A组基础上第3天起给予维生素E口服,2.5 mg.kg-1.d-1,连用4周;C组在A组基础上第3天起给予维生素E口服,15.0 mg.kg-1.d-1,连用4周。观察3组治疗前,治疗后第1周、第2周、第3周、第4周血细胞比容(Hct)、血红蛋白(Hb)、红细胞计数(RBC)、网织红细胞计数(Ret);同时观察3组治疗前后血清维生素E水平。结果治疗前与治疗后第1周3组早产儿Hct、Hb、RBC、Ret比较,差异均无统计学意义(P>0.05);治疗后第2周、第3周、第4周3组早产儿Hct、Hb、RBC、Ret比较,差异均有统计学意义(P<0.05),且B组、C组Hct、Hb、RBC均高于A组,B、C组Ret均低于A组,而B、C组之间Hct、Hb、RBC、Ret比较,差异均无统计学意义(P>0.05)。3组早产儿治疗前血清维生素E水平比较,差异无统计学意义(P>0.05);3组早产儿治疗后血清维生素E水平比较,差异有统计学意义(P<0.05),且B组、C组血清维生素E水平高于A组(P<0.05),C组血清维生素E水平高于B组(P<0.05)。结论小剂量(2.5 mg.kg-1.d-1)维生素E治疗即可改善早产儿贫血症状,建议小剂量口服维生素E以预防早产儿贫血。Objective To evaluate the therapeutic effects of different dosages of vitamin E in preventing anemia in pre- mature children. Methods A total of 60 cases of premature children admitted to the NICU ward of our hospital between October 2009 and October 2011 were divided into three groups （Group A, B, C; n = 20 for each group） in chronological order. Ba- bies in all groups were given conventional formula and partial intravenous nutritional support. Babies in Group B were given addi- tional oral intake of vitamin E 2. 5 mg . kg -1 . d-1and babies in Group C were given additional oral intake of vitamin E 15 mg . kg-1 . d-l from the third day for 4 consecutive weeks. The hematocrit （Hct）, hemoglobin （Hb）, red blood cell （RBC）, and retieuloeyte （Ret） were observed and recorded before the treatment, and at 1 week, 2 weeks, 3 weeks, and 4 weeks after the treatment. Levels of vitamin E before and after treatment were also observed. Results No significant differences were ob- served among the three groups in Hct, Hb, RBC, and Ret before the treatment and at 1 week after the treatment （ P 〉 0. 05 ）, but the differences appeared at week 2, week 3, and week 4 after the treatment （ P 〈 0. 05 ）. Group B and C had higher Hct, Hb, and RBC, but lower Ret than Group A. No significant difference was observed between Group B and C in Hct, Hb, RBC, and Ret （ P 〉 0. 05 ）. Significant difference in level of serum vitamin E among the three groups was not observed before the treat- ment but after （ P 〈 0. 05 ）. Group B and C had higher level of vitamin E than Group A, and Group C had higher level of vita- min E than Group B （ P 〈 0. 05 ）. Conclusion Low dosage of vitamin E （ 2. 5 mg . kg-1 . d -1 ） can improve the anemia svmotoms of oremature babies and might be used to orevent anemia in oremature babies.

关 键 词：维生素E 贫血 早产儿 治疗结果 综合预防 

分 类 号：R725.6[医药卫生—儿科]