急性心肌梗死患者高敏C反应蛋白浓度变化及阿托伐他汀的干预效应  

Effect of Atorvastatin on High-sensitivity C-reactive Protein in Acute Myocardial Infarction

作　　者：罗贵全 黄刚[1] 唐川苏 邓学军[1] 何小君[1] 周明刚[1] 

机构地区：[1]四川省遂宁市中心医院

出　　处：《中西医结合心脑血管病杂志》2013年第9期1074-1075,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的研究急性心肌梗死(acute myocardial infarction,AMI)患者高敏C反应蛋白(high-sensitivity C reactive protein,hs-CRP)浓度变化及阿托伐他汀的干预效应。方法将2011年1月-2012年12月在遂宁市中心医院就诊的64例AMI患者分为阿托伐他汀低剂量组(20mg/d)、阿托伐他汀高剂量组(40mg/d);32例健康体检者为对照组,每组32例。分别测定治疗前及治疗7d后AMI患者hs-CRP和血脂的浓度并进行比较分析。结果治疗前AMI患者的hs-CRP、总胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白胆固醇(LDL-C)的浓度显著高于对照组(P<0.05)。治疗7d后低剂量组和高剂量组的hs-CRP、TC、TG和LDL-C的浓度较治疗前显著降低(P<0.05),并且高剂量组较低剂量组的降低幅度更大(P<0.05)。但是两组治疗7d后的hs-CRP、TC和LDL-C浓度仍高于对照组(P<0.05)。结论 AMI患者hs-CRP水平明显升高,阿托伐他汀能明显降低AMI患者hs-CRP浓度,高剂量阿托伐他汀更能显著抑制AMI的炎症反应。Objective To investigate the effect of atorvastatin on high - sensitivity C reactive protein （hs - CRP） in patients with acute myocardial infarction （AMI）. Methods Sixty patients with AMI were randomly assigned to low dose group （20 mg/d atorvastatin）, high dose group （40 mg/d atorvastatin） ,and 32 health subjects were as control group. Concentrations of plasma hs - CRP and blood lipids were detected and compared before treatment and after treatment for 7 days. Results Concentrations of plasma hs - CRP,total cholesterol （TC）,triglyeerides （TG） and low density lipoprotein cholesterol （LDL- C） in AM1 patients before treatment were obviously higher than that in control group （P〈0. 05）. After treatment for 7 days, concentrations of plasma hs -CRP,TC,TG and LDL- C were decreased significantly in low dose group and high dose group （P〈0.05）. Concentrations of plasma hs- CRP,TC and LDL - C in high dose group were decreased more significantly than that in low dose group （P〈0.05）. Concentrations of plasma hs- CRP,TC and LDL-C in both low dose group and high dose group after 7 days treatment were still higher than that in control group （P〈0.05）. Conclusion The concentration of plasma hs - CRP was increased obviously in patients with AMI,which could be significantly decreased by atorvastatin. High dose atorvastatin could more notably suppress inflammatory reaction in AMI.

关 键 词：急性心肌梗死 炎症 C反应蛋白 阿托伐他汀 血脂 

分 类 号：R542.22[医药卫生—心血管疾病]