3,4,5,6-四溴酚磺酞合成及纯化方法的改进  

Method Improvement of Synthyesis and Purification of 3,4,5,6-Tetrabromophenolsulfonephthalein

作　　者：修志明[1] 黄梦媛[1] 胡冰[1] 雷莉妍[1] 王丽萍[1] 

机构地区：[1]吉林大学生命科学学院,长春130012

出　　处：《吉林大学学报（理学版）》2013年第5期965-968,共4页Journal of Jilin University:Science Edition

基　　金：吉林省自然科学基金(批准号:201015171);吉林省科技发展计划项目(批准号:201205017);吉林省医药产业发展专项基金(批准号:YYZX201150-2)

摘　　要：以2-磺基苯甲酸环酐为原料,溴代后与苯酚反应合成3,4,5,6-四溴酚磺酞粗产品,并用溶剂抽提和重结晶方法进行纯化.结果表明,所得产物的纯度为97.45%,收率为36.5%.3, 4, 5, 6-Tetrabromophenolsulfonephthalein was synthesized by the reaction of 2-sulfobenzoic acid cyclic anhydride suffered from bromination with phenol. The crude product was purified by solvent extraction and recrystallization with a purity of the product of 97. 45% and a yield of 36.5%, respectively.

关 键 词：2-磺基苯甲酸环酐 3 4 5 6-四溴酚磺酞 纯化 

分 类 号：Q503[生物学—生物化学]