无溶剂下磷钨酸镧催化合成5-亚烃基-2,2-亚丁基-1,3-二噁烷-4,6-二酮  

Solvent-Free Synthesis of 5-Alkenyl-2,2-Butylidene-1,3-Dioxane-4,6-Diones with LaPW_(12) O_(40) as Catalyst

作　　者：许招会[1] 熊斌[1] 雷志伟[1] 

机构地区：[1]江西师范大学化学化工学院,江西南昌330027

出　　处：《江西师范大学学报（自然科学版）》2013年第4期337-341,共5页Journal of Jiangxi Normal University(Natural Science Edition)

基　　金：江西科技国际合作课题(kj082563);江西省研究生创新专项基金(YC10A051)资助项目

摘　　要：在LaPW12O40催化下,芳香醛和2,2-亚丁基-1,3-二噁烷-4,6-二酮在无溶剂条件下合成了8种新型5-亚烃基-2,2-亚丁基-1,3-二噁烷-4,6-二酮.当催化剂的用量为5%（摩尔分数）时,室温反应20~40 min,收率为87.6%~94.3%.此外,还探讨了LaPW12O40的催化机理.该方法具有条件温和,反应时间短且收率高的优点.催化剂LaPW12O40对环境友好且可循环利用.Eight kinds of 5-alkenyl-2,2-butylidene-1,3-dioxane-4,6-diones were synthesized by the Knoevenagel condensation reaction of aromatic aldehydes with 2,2-pentamethylene-1,3-dioxane-4,6-dione using LaPW 12 O 40 as catalyst,without solvent.The results indicate that the yields ranged from 87.6% ~ 94.3%,when using 5%（molar fraction） LaPW 12 O 40 and reacting at room temperature for 20 ~ 40 min.Furthermore,a proposed reaction mechanism for the reaction catalyzed by LaPW 12 O 40 was speculated.Compared to the classical Knoevenagel condensation reaction,the main advantages of the present procedure were milder conditions,shorter reaction time and higher yields,which afforded an effective method to synthesize 5-alkenyl-isopropylidene malonate derivatines.Further study showed that LaPW 12 O 40 was environmentally friendly and reused for four times without any noticeable decrease in the catalytic activity.

关 键 词：2 2-亚丁基-1 3-二噁烷-4 6-二酮 磷钨酸镧 芳香醛 缩合反应 

分 类 号：O621.25[理学—有机化学]