2,3-二氨基吡啶的合成研究  

Synthesis of Pyridine-2,3-diamine

作　　者：赵春深[1,2] 宋吾燕[1,2] 吴昌云[1,2] 吴省付[1,2] 王思东[1,2] 

机构地区：[1]贵州省发酵工程与生物制药重点实验室,贵州贵阳550025 [2]贵州大学化学与化学工程学院,贵州贵阳550025

出　　处：《广州化工》2013年第18期56-57,共2页GuangZhou Chemical Industry

基　　金：贵阳市科学计划项目(现代药业计划);合同编号:筑科合同[2012204]号

摘　　要：氨基吡啶类化合物是重要的有机化工原料，是合成许多精细化学品的中间体，在农药、医药、高分子及含能材料等领域有广泛的应用。对氨基吡啶类化合物的合成研究非常有意义。文章介绍了标题化合物的合成方法。以2，6-二氯吡啶为起始原料，经硝化、氨基取代、还原3步反应合成了目标化合物，并经MS和1_HNMR对其结构进行了表征。本合成路线原料廉价易得、反应条件温和、操作方便，是一种适合于工业化生产的新方法。反应的总收率57％。Amino pyridines were important chemical materials and intermediates, which were widely used in pharmacy, energetic and polymer- materials industry. Therefore, the research about their synthetic routes was still in great desire. The approach to synthesize the title compound was introduced, which was realized and manufactured from 2, 6- dichloropyridine via three steps. Its structure was verified by MS and I H NMR. This synthetic route had the advantages of convenient operation and mild reaction conditions. The total product yield was 57%. This program was suitable for industrial production.

关 键 词：2 3-二氨基吡啶 2 6-二氯吡啶 合成 

分 类 号：O626.3[理学—有机化学]