血降钙素原和血C-反应蛋白在AECOPD的临床意义  

Study of the clinical significance of procalcitonin and C-reactive protein for the treatment in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：董琳 王继灵[1] 吴桂平[1] 胡召锁 杨庆斌[1] 

机构地区：[1]合肥市第二人民医院呼吸内科,安徽合肥230011 [2]合肥市第二人民医院检验科,安徽合肥230011

出　　处：《临床肺科杂志》2013年第11期1961-1963,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的评价血降钙素原(PCT)和血C-反应蛋白(CRP)在指导慢性阻塞性肺疾病急性加重期(AECOPD)抗菌治疗策略中的价值。方法入选38例AECOPD患者,随机分为血PCT和血CRP指导组(n=18)和标准组(n=20)。主要观察两组指标为临床有效率、加重例数、住院天数(天)、二重感染例数、死亡例数等。同时对比观察血PCT与血CRP关系。结果血PCT和血CRP指导组较标准组在使用抗生素时间、住院时间、易早期发现真菌感染、花费明显减少。血指标升高,血CRP也随着升高。结论血PCT和血CRP联合具有指导AECOPD抗菌治疗的作用,能够减少抗生素过度使用,降低二重感染机会。Objective To evaluate the value of procalcitonin （PCT） and C-reactive protein （CRP） in guiding the strategies of antibacterial treatment in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods 38 hospitalized AECOPD patients were randomized into PCT and CRP steering group （n = 18 ） and criterion group （n = 20）. Main observational in- dexes are as following： clinical efficiency, the number of aggravated cases, days of hospitalization, the number of secondary infection cases and deaths. At the same time, the relationship between their PCT and CRP was observed. Results In comparison with criterion group, the days of antibiotics use, days of hospitalization, time to the detection of fungal infection and expense reduced dramatically in PCT and CRP steering group. The rise of CRP index went with the rise of PCT index. Conclusion The combination of PCT and CRP functioned effectively in guiding the antibacterial treatment in patients with AECOPD and reduced the excessive antibiotics use and the chance for secondaxy infection.

关 键 词：慢性阻塞性肺疾病 血PCT 血CRP 抗菌药 

分 类 号：R563.9[医药卫生—呼吸系统]