西地那非预防早产儿支气管肺发育不良疗效观察  

Clinical observation on the effect of prophylactic usage of sildenaffi for the prevention of neonatal bronchopulmo- nary dysplasia

作　　者：王洲洪[1] 韩进天[2] 李格花[2] 黄爱华[1] 谢建兴[1] 周延琅[1] 谢彤[1] 

机构地区：[1]广西玉林市第二人民医院新生儿科,537000 [2]广西玉林市第一人民医院新生儿科

出　　处：《中国生育健康杂志》2013年第5期367-370,共4页Chinese Journal of Reproductive Health

摘　　要：目的探讨应用西地那非预防早产儿支气管肺发育不良（BPD）的临床价值。方法69例机械通气早产儿预防性口服西地那非治疗，69例未使用西地那非治疗，但其他治疗条件相同。结果肺动脉血流速度、心输出量、PaO2、OI、PaO2／FiO2，两组治疗12h、24h、7d和28d后的与治疗前比较，差异均有统计学意义；两组各治疗时间点比较，差异均有统计学意义；心率和血压与治疗前比较，差异均无统计学意义；西地那非组各时问点的FiO2、PaCO2与对照组相比，差异均无统计学意义。生后28d息儿发生BPD，西地那非组和非西地那非分别为8．7％和21．7％，差异有统计学意义。结论预防性口服西地那非可降低早产儿BPD的发生率或改善BPD的严重程度，在推荐应用剂量范围内未发现明显不良反应，值得临床应用推广。Objective To evaluate the effect of prophylactic usage of sildenalil for the prevention of neonatal bron- chopulmonary dysplasia （BPD）. Methods Prospective observation on 138 premature infants with mechanical ventila- tion, who were hospitalized curing July 2007 to November 2012. The patients were randomly divided into the sildenafil group and the control group, with 69 cases in each group. Oral sildenalil was given to each case in the sildenafil group; the control group received other treatment but no sildenafil. The two groups were compared before and after the treatment in terms of pulmonary mean blood flow velocity, cardiac output, heart rate, blood pressure, arterial partial pressure of oxygen （ PaO2 ）, arterial partial pressure of carbon dioxide （ PaCO2 ）, oxygenated index （ OI）, and PaOJFiO2. After 28 days of treatment, we compared the frequency of BPD between the two groups, while checking chest radiography. Results Both groups improved after treatment at 12 hours, 24 hours, 7 days, and 28days, with regard of pulmonary blood flow velocity, cardiac output, PaO2 , OI, and PaO2/FiO2 when compared with before treatment. At each time point of treatment, the two groups showed difference in pulmonary blood tlow velocity, cardiac output, PaO2, OI, and PaO2/FiO2. Heart rate and blood pressure had no change after the treatment. No differences were observed in PaCO2 and FiO2 between the two groups at either time point of treatment. After 28 days of treatment, 6 cases development BPD （8.7 % ） in the sildenafil group, compared with 15 cases （ 2 1. 7 % ） in the control group. Conclusion Prophylactic usage of sildenafil can reduce the oc- currence of premature BPD.

关 键 词：西地那非 支气管肺发育不良 新生儿 

分 类 号：R722.6[医药卫生—儿科]