25-羟维生素D_3水平与婴幼儿下呼吸道感染的关系  

The Correlations of Serum 25-Hydrovitamin D_3 Level and the Lower Respiratory Infection in Infants

作　　者：孙秋凤[1] 严永东[1] 陈正荣[1] 王宇清[1] 黄莉[1] 黄凤[1] 季伟[1] 缪美华[1] 

机构地区：[1]苏州大学附属儿童医院,江苏苏州215003

出　　处：《儿科药学杂志》2013年第9期1-3,共3页Journal of Pediatric Pharmacy

基　　金：苏州市科技发展计划项目;编号:SYSD2012095

摘　　要：目的:探讨血清25-羟维生素D3[25-(OH)D3]水平与婴幼儿急性下呼吸道感染的关系及临床意义。方法:选取2011年11月至2012年5月在我院呼吸科住院的65例下呼吸道感染患儿,分为普通肺炎组35例与重症肺炎组30例,采用ELISA法测定其血清中25-(OH)D3水平,选择同期在我院儿童保健科体检的40例健康婴幼儿作为对照组。结果:(1)重症肺炎组、普通肺炎组、对照组血清25-(OH)D3水平分别为(51.92±17.65)nmol/L、(63.51±18.47)nmol/L、(79.49±18.97)nmol/L,各组间比较差异有统计学意义(P<0.01);(2)重症肺炎组患儿维生素D缺乏率为36.7%,显著高于对照组的7.5%(P<0.01)。结论:肺部感染患儿血清25-(OH)D3水平低于健康儿童,在重症肺炎患儿中更明显;重症肺炎患儿维生素D缺乏率显著高于健康儿童。因此,维生素D在呼吸道感染的发生及发展中具有重要作用。Objective： To investigate the correlations between the serum 25-hydrovitamin D3 [ 25-（ OH ）D3 ] level and the lower respiratory infection in infants. Methods： Detect the serum 25- （OH） D3 of sixty-five hospitalized children with lower respiratory infection by using ELISA during November 2011 to May 2012. They were divided into a common pneumonia group and a severe pneumonia group, while forty healthy children were enrolled as a control group. Results： （1） The average levels of 25-（OH） D3 of the severe pneumonia group, the common pneumonia group and the control group were （51. 92± 17. 65 ） nmol/L, （63. 51± 18. 47 ） nmol/L, and （79.49±18.97） nmol/L respectively, the difference between the groups was remarkable （P〈0.01） ; （2） The proportion of vitamin D deficiency in severe pneumonia cases was 36.7%, which was higher than that in healthy children （7.5%, P〈0.01 ）. Conclusions： The levels of 25-（OH） D3 in children with lung infection was lower than those in healthy children. This phenomenon is more obvious in children with severe pneumonia. Vitamin D deficiency rate was higher in severe pneumonia children than those in healthy children. Vitamin D may play an important role in the occurrence and progress of respiratory infections.

关 键 词：下呼吸道感染 重症肺炎 25-羟维生素D3 

分 类 号：R725.6[医药卫生—儿科]