发病前使用他汀类药物对急性缺血性脑卒中患者静脉溶栓疗效的影响  

Efficacy of statins therapy prior to acute ischemic stroke on intravenous thrombolysis:report of 181 cases

作　　者：欧阳宛炯[1] 黄银辉[2] 李明媚 卓仕途[1] 陈振杰 李隽静[1] 张碧月[1] 叶励超[1] 蔡若蔚[1] 

机构地区：[1]福建医科大学附属第二医院神经内科,福建泉州362002 [2]解放军第180医院神经内科,福建泉州362008 [3]安溪县铭选医院神经内科,福建泉州362400

出　　处：《第三军医大学学报》2013年第18期1980-1983,共4页Journal of Third Military Medical University

摘　　要：目的探讨发病前使用他汀类药物治疗对急性缺血性脑卒中患者静脉溶栓疗效的影响。方法从2006年4月到2012年11月连续收集发病6 h内静脉溶栓治疗的181例急性缺血性脑卒中患者作为研究对象。根据发病前有无使用他汀类药物将患者分为使用他汀类药物组和未使用他汀类药物组。采用改良的Rankin量表评价神经功能恢复状况。结果 181例患者中发病前使用他汀类药物的溶栓治疗组30例,未使用他汀类药物的溶栓治疗组151例。两组在90 d内溶栓预后良好率(50.00%vs 56.95%,P=0.166)、颅内出血的发生率(26.67%vs 18.54%,P=0.309)、症状性颅内出血的发生率(16.67%vs 11.26%,P=0.408)及病死率(10.00%vs 4.64%,P=0.240)均无统计学差异。结论发病前使用他汀类药物对急性缺血性脑卒中患者静脉溶栓疗效无影响且安全。Objective To determine the effect of taking statin drugs before stroke onset on the outcome of thrombolytic therapy in thrombolysis patients within 6 h after acute ischemic stroke.Methods A total of 181 consecutive patients with acute ischemic stroke undergoing intravenous therapy with in 6 h from symptom onset during April 2006 to November 2012 were enrolled in this study.According to whether having prior administration of statin drugs,the parents who met the inclusion criteria were divided into 2 groups,prior use of statin drugs group（n = 30） and the non-prior use of statin drugs group（n = 151）.Same thrombolytic therapy was carried out to the 2 groups of patients.Modified Rankin Scale were used to evaluate the recovery of neurological functions.All patients were followed up by once per month,for 3 months.Results There was no significant difference in the efficacy of good prognosis（50.00% vs 56.95%,P = 0.166）,the incidence of intracranial hemorrhage（26.67% vs 18.54%,P = 0.309）,the prevalence of symptomatic intracranial hemorrhage（16.67% vs 11.26%,P = 0.408）,and the mortality（10.00% vs 4.64%,P = 0.240） between the 2 groups.Conclusion The prior use of statin drugs has no effect on the therapeutic efficiency and saftety of thrombolytic therapy.Intravenous thrombolysis therapy is safe for patients with acute ischemic stroke but taking stain drugs before stroke onset.

关 键 词：他汀类药物 急性缺血性脑卒中 溶栓 疗效 

分 类 号：K453.9[历史地理—历史学] R743.33[历史地理—世界史]