氯诺昔康复合吗啡应用于肺叶切除术后持续镇痛的临床研究  

Persistent abirritation by using lornoxicam combined with morphine after pulmonary lobectomy

作　　者：王育栋[1] 王燕[1] 仲华[1] 杨国生[1] 郝光延[1] 罗天仁[1] 马仲浩[1] 

机构地区：[1]解放军第十医院麻醉科,甘肃武威733000

出　　处：《西北国防医学杂志》2013年第5期427-429,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:观察氯诺昔康持续静脉镇痛复合吗啡硬膜外镇痛用于肺叶切除术后患者的镇痛效果及安全性。方法:开胸行肺叶切除术的患者40例,随机分为A组(20例)和B组(20例)。在手术结束前30 min,A、B两组均于硬膜外腔注入含吗啡2 mg的0.25%布比卡因6 ml,并接PCA镇痛泵。A组为静脉镇痛,含氯诺昔康0.8 mg/kg;B组为硬膜外镇痛,含0.5%布比卡因20 ml,吗啡0.1 mg/kg。记录各组的疼痛强度值(VAS评分)、术后36 h患者对镇痛效果满意程度及不良反应。结果:A组术后疼痛VAS评分显著低于B组,且镇痛效果的满意度高。两组的不良反应发生率无显著性差异。结论:开胸肺叶切除术后应用氯诺昔康静脉持续镇痛复合吗啡硬膜外镇痛,其镇痛效果更强,且安全可靠。Objective： To assess the abirritation and security of lornoxicam combined with morphine after pulmo- nary lobectomy. Methods： Forty patients underwent pulmonary lobectomy were randomly divided into group A （ n = 20） and group B （ n = 20） . The two groups both have 20 patients. All patients injected 0.25 mg morphine and 1.25 mg bupivacaine into epidural cavity and received postoperative PCA 30 minutes before operation finished. Group A used lornoxicam 0.8 mg/kg by venous channel, while group B used morphine 0.1 mg/kg and 10 mg bupi- vacaine by epidural way. Then pain scores （AS） , satisfactory grade of analgetic effect and side effects in 36 hours were recorded and analyzed. Results ：There were significant differences in pain scores （VAS） and satisfacto- ry grade of analgetic effects between group A and group B, while little difference in side effects between the two groups. Conclusion： Lornoxicam by venous channel combined with morphine by epidural way is more effective in abirritation and safer after oulmonarv lobectomv.

关 键 词：麻醉学 氯诺昔康 吗啡 肺叶切除术 

分 类 号：R614[医药卫生—麻醉学]