CYP11B2多态性与中国汉族原发性高血压关联的荟萃分析  

Meta analysis on the association of CYPllB2 gene polymorphism and essential hypertension in Chinese Han population

作　　者：叶雯婧[1,2] 郑铃[1] 王征桦[1,2] 陈欢欢[1] 

机构地区：[1]福建医科大学公共卫生学院流行病与卫生统计学系,福州350108 [2]福建省人兽共患重点实验室福建省疾病预防与控制中心,福州350108

出　　处：《中华心血管病杂志》2013年第9期795-799,共5页Chinese Journal of Cardiology

摘　　要：目的 荟萃分析评价CYP11B2-344C/T多态性与中国汉族原发性高血压易感及血压水平的关联。 方法 检索相关数据库，收集国内外研究CYP11B2-344C/T多态性与中国汉族原发性高血压关联的文献，依据NEWCASTLE-OTTAWA病例对照研究质量评定量表（NOS）评价文献质量，应用Stata选择最佳遗传模型，分析异质性和计算合并OR、收缩压和舒张压的标准化均数差（SMD）值及95% CI。 结果 研究对象共计9249例，原发性高血压与对照组CC比TT、CT比TT、CC比CT的OR（95% CI）值依次为1.022（95%CI：0.879～1.190）、1.108 （95% CI： 0.951～1.291）、1.050 （95% CI： 0.995～1.109）；收缩压（共显性模型）CC比TT的SMD值及95% CI为0.315 （0.066-0.565），Z=2.48，P=0.013，CT比TT的SMD值及95% CI为0.088（0.014-0.162），Z=2.24，P=0.019。 结论 C等位基因的携带可使中国汉族人群收缩压上升，尚无证据证明CYP11B2（-344C/T）多态性与中国汉族原发性高血压易感有关联。Objective To explore the association between CYP11B2 gene polymorphism and essential hypertension, blood pressure level in Chinese Han population by meta-analysis. Methods After searching database, the research quality was quantified according to NOS. Genetic model, heterogeneity, publication bias, overall OR/standardized mean difference （SMD） and 95% CI were explored by Stata, 19 studies including 9249 subjects were included in this meta-analysis. Results Compared to control group, OR（95% CI） of CC vs. TT, CT vs. TT, CC vs. CT in essential hypertensive patients were 1. 022 （95% CI： 0. 879 - 1. 190） ,1. 108 （95% CI： 0. 951 - 1. 291 ）, 1. 050（95% CI：0. 995 - 1. 109）, respectively; SMD （95%CI） was 0. 315 （0. 066 - 0. 565, P 〈 0. 05 ） for systolic pressure derived CC vs. TT, and 0. 088 （0. 014- 0. 162, P 〈 0. 05 ） for CT vs. TT. Conclusion Individuals with -344C CYP11B2 allele are at higher risk of increased systolic blood pressure, but there is no evidence showing association between CYP11 B2 polymorphism and susceptibility of essential hypertension in Chinese Han population.

关 键 词：高血压 多态性 单核苷酸 荟萃分析 

分 类 号：R544.1[医药卫生—心血管疾病]