弯曲应力作用下兔胫骨骨干皮质骨的骨重建方式  

Bone remodeling of rabbit tibia diaphysis cortical bone under bending force

作　　者：王宇[1] 李成梅[1] 李玉生[1] 张志刚[1] 

机构地区：[1]解放军第208医院,吉林省长春市130062

出　　处：《中国组织工程研究》2013年第37期6548-6554,共7页Chinese Journal of Tissue Engineering Research

基　　金：吉林省自然科学基金项目(201015123)~~

摘　　要：背景:骨所承受的应力变化是骨重建的重要刺激源。目前应力与骨重建关系的研究集中在轴向应力对骨重建的影响,而对弯曲应力环境下的骨重建模式缺乏研究。目的:观察在长期弯曲应力作用下生长期兔胫骨骨干皮质骨骨重建的方式。方法:在兔左胫骨近端内侧骨骺线远侧0.5 cm处开一直径2.5 mm骨窗,用冰盐水将兔胫骨及记忆合金片降温,降温后将记忆合金片拉直后经骨窗置入胫骨髓腔。记忆合金置入方向:使其复温后两端抵在外侧骨皮质上,弧形顶点抵向内侧骨皮质,缝合伤口。通过胫骨髓腔内置入的形状记忆合金片,给予兔胫骨骨干内部施加持续弯曲应力,观察胫骨骨干皮质骨在长期弯曲应力环境下骨重建的模式。结果与结论:在6个月持续弯曲应力作用下,兔胫骨骨干张应力侧骨皮质变薄,压应力侧骨皮质增厚,胫骨未观察到明显弯曲形变,压力侧骨皮质增厚程度与胫骨上的应力分布有关。结构完整的胫骨对弯曲应力表现出一种内在的"抗性",说明无骨折长骨骨干部分基本上不具备力线矫正潜力。实验结果提示,弯曲应力下兔胫骨骨干皮质骨骨重建模型创伤小,应力可控,不影响骨的生长和代谢,不限制实验动物活动,更符合生理状态,是一个理想的骨重建动物模型。BACKGROUND： The stress changes of bone are the main simulation sources for bone remodeling. At present, the research on the relationship between stress and bone remodeling focuses on the effect of axial stress on bone remodeling, while the research on bone re.m0deling under bending force is rare. OBJECTIVE： To observe the bone remodeling of rab. bit tib.ia diaphysis cortical bone in growth phase under bending.force. METHODS： A bone window with the diameter of 2.5 mm was made 0.5 cm from the medial d!stal epiphyseal line of rabbit proximal left tibia, and then ice saline was used to cool the tibia and memory alloy film. After co0!ing, the memory alloy stripe was straightened and implanted into the tibial bone marrow cavity through the bone window. The direction of memory alloy stripe implantation： two ends of the memory alloy stripe arrived to the lateral cortex after rewarming, and the curve apex arrived to the medial cortical bone, followed by the sutured wound. The continuous internal bending force was loaded on the rabbit tibia diaphysis through the shape memory alloy stripe implanted into the tibial bone marrow cavity in order to observe the bone remodeling mode of tibia diaphysis cortical bone under long-term bending force.

关 键 词：胫骨 骨干 应力 物理 合金 模型 动物 

分 类 号：R318[医药卫生—生物医学工程]